Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes.
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Summary
It is demonstrated that PGE2 selectively and dose dependently inhibits IL-2 and IFN-gamma production by mitogenically stimulated human PBL and CD4+ TLC, although at low concentrations IL-4 production is not affected and IL-5 production is even up-regulated.
- Type
- article
- Published
- 1993-06-15
- Cited by
- 524
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W1647832452
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7708568
Keywords
Forskolin, Secretion, Intracellular, Cytokine, Endocrinology
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