Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein
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Summary
A unique cellular gene, CEM15, is described, whose transient or stable expression in cells that do not normally express CEM15 recreates this phenotype, but whose antiviral action is overcome by the presence of Vif.
- Type
- article
- Published
- 2002-08-08
- Cited by
- 558
- References
- 58
- OpenAlex
- https://openalex.org/W2001375348
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:272200280
Keywords
Biology, Virology, Infectivity, Viral replication, Phenotype
References
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- The Vif protein of human and simian immunodeficiency viruses is packaged into virions and associates with viral core structures
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- Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
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- Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein
- The human immunodeficiency virus type 1 Vif protein modulates the postpenetration stability of viral nucleoprotein complexes
- Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells
- Fv-1 restriction and its effects on murine leukemia virus integration in vivo and in vitro
- Mutations affecting transition-state stabilization by residues coordinating zinc at the active site of cytidine deaminase.
- The sor gene of HIV-1 is required for efficient virus transmission in vitro.
- Molecular cloning of an apolipoprotein B messenger RNA editing protein.
- Isolation and characterization of a novel gene from the DiGeorge chromosomal region that encodes for a mediator subunit.
- Quantitative infectivity assay for HIV-1 and -2
- sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction.
- Cytosine nucleoside/nucleotide deaminases and apolipoprotein B mRNA editing.
- Mutagenesis of apobec-1, the Catalytic Subunit of the Mammalian Apolipoprotein B mRNA Editing Enzyme, Reveals Distinct Domains That Mediate Cytosine Nucleoside Deaminase, RNA Binding, and RNA Editing Activity (*)
Cited by
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- Cellular Restriction Factors of Feline Immunodeficiency Virus
- MCPIP1 restricts HIV infection and is rapidly degraded in activated CD4+ T cells
- HIV-1 Replication and the Cellular Eukaryotic Translation Apparatus
- Conservation and Innovation of APOBEC3A Restriction Functions during Primate Evolution.
- Crystal structures of APOBEC3G N-domain alone and its complex with DNA
- Repression of MicroRNA Function Mediates Inflammation-associated Colon Tumorigenesis.
- Lentiviral gene therapy for HIV using TRIM-cyclophilin restriction factors
- Interactions du VIH-1 avec ses cellules cibles : recherche de nouveaux réservoirs et analyse du contrôle de la latence
- MESSA A PUNTO DI TEST ALTERNATIVI PER LO SCREENING DI POTENZIALI INIBITORI DELLA PROTEASI DI HIV-1
- Antigen presentation: Mapping the maze
- Factores de transcrição artificiais na identificação de genes celulares importantes na infecciosidade do HIV-1
- Determinants of HIV-1 Gag Localization to Uropods in Polarized T Cells and the Role Uropods Play in Virus Spread.
- HIV Suppression by Host Restriction Factors and Viral Immune Evasion
- Determination of the secondary structure of minus strong-stop DNA and the mechanism of annealing involved in the first strand transfer in HIV-1
- Rôle de la lysyl-ARNt synthétase mitochondriale humaine dans la réplication du VIH-1
- A Mechanistic Examination of APOBEC3-Mediated LINE-1 Inhibition.
- Three Cardiovirus Leader Proteins Equivalently Inhibit Four Different Nucleocytoplasmic Trafficking Pathways
- Redoxal, an Inhibitor of De Novo Pyrimidine Biosynthesis, Augments APOBEC3G Antiviral Activity Against Human Immunodeficiency Virus Type 1
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