Mutations affecting transition-state stabilization by residues coordinating zinc at the active site of cytidine deaminase.

Keywords

Zinc, Enzyme kinetics, Cytidine deaminase, Chemistry, Enzyme

References

• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.Richard W. McEnally, Rebecca B. Todd — 1976
• Metal-free dialysis tubing.David S. Auld — 1988
• T4-phage deoxycytidylate deaminase is a metalloprotein containing two zinc atoms per subunit.John T. Moore, Ruth E. Silversmith, Gladys F. Maley — 1993
• Cytidine deaminase from Escherichia coli. Purification, properties and inhibition by the potential transition state analog 3,4,5,6-tetrahydrouridine.Robert M. Cohen, Richard Wolfenden — 1971
• The p27 catalytic subunit of the apolipoprotein B mRNA editing enzyme is a cytidine deaminase.Naveenan Navaratnam, John R. Morrison, Shoumo Bhattacharya — 1993
• Refined crystal structure of carboxypeptidase A at 1.54 A resolution.Douglas C. Rees, Mark P. Lewis, William N. Lipscomb — 1983
• Crystal structure of human carbonic anhydrase C.Anders Liljas, K. K. Kannan, Per-Christer Bergstén — 1972
• Binding of pyrimidin-2-one ribonucleoside by cytidine deaminase as the transition-state analogue 3,4-dihydrouridine and the contribution of the 4-hydroxyl group to its binding affinity.Lloyd Frick, Charles C. Yang, Víctor E. Márquez — 1989
• Degradation of Abnormal Proteins in Escherichia coliAlfred L. Goldberg — 1972
• Crystal structure of human erythrocyte carbonic anhydrase B. Three-dimensional structure at a nominal 2.2-A resolution.K. K. Kannan, B Notstrand, K. Fridborg — 1975
• Atomic structure of adenosine deaminase complexed with a transition-state analog: understanding catalysis and immunodeficiency mutations.David K. Wilson, Frederick B. Rudolph, Florante A. Quiocho — 1991
• Refined 2.5 A structure of murine adenosine deaminase at pH 6.0.Andrew Sharff, David K. Wilson, Zengyi Chang — 1992
• Transition-state characterization: a new approach combining inhibitor analogues and variation in enzyme structure.Margaret A. Phillips, Alan P. Kaplan, William J. Rutter — 1992
• Zinc coordination, function, and structure of zinc enzymes and other proteins.Bert L. Vallée, David S. Auld — 1990
• The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate-modified DNA.W. John Taylor, Johann Ott, Fritz Eckstein — 1985
• An octamer of histones in chromatin and free in solution.Jean Thomas, Roger D. Kornberg — 1975
• Stereospecific and regiospecific photoreactions inside the channels of the choleic acidsRonit Popovitz‐Biro, Hao‐Ching Chang, Cheng Tang — 1980
• Cytidine deaminase. The 2.3 A crystal structure of an enzyme: transition-state analog complex.Laurie Betts, Shibin Xiang, Steven A. Short — 1994
• Cloning and nucleotide sequence of the Escherichia coli cytidine deaminase (ccd) gene.Charles C. Yang, Dean C. Carlow, Richard Wolfenden — 1992
• Phosphonamidates as transition-state analogue inhibitors of thermolysin.Paul A. Bartlett, Charles K. Marlowe — 1983

Cited by

• The flexible C-terminal region of Aspergillus terreus blasticidin S deaminase: identification of its functional roles with deletion enzymes.Constantin Pop — 2002
• Gut hormone PYY3-36 physiologically inhibits food intakeHerbert J. Klausmeier, George T. O’Hearn — 2002
• Transition state and multisubstrate analog inhibitors.Anna Radzicka, Richard Wolfenden — 1995
• A Single Zinc Ion Is Sufficient for an Active Trypanosoma brucei tRNA Editing Deaminase*Jessica L. Spears, Mary Anne T. Rubio, Kirk W. Gaston — 2011
• A Cytidine Deaminase Edits C to U in Transfer RNAs in ArchaeaLennart Randau, Bradford Stanley, Andrew Kohlway — 2009
• Free‐flow electrophoresis for top‐down proteomics by Fourier transform ion cyclotron resonance mass spectrometrySéverine A. Ouvry‐Patat, Matthew P. Torres, Hung‐Hiang Quek — 2008
• Mutagenesis of apobec-1, the Catalytic Subunit of the Mammalian Apolipoprotein B mRNA Editing Enzyme, Reveals Distinct Domains That Mediate Cytosine Nucleoside Deaminase, RNA Binding, and RNA Editing Activity (*)Andrew J. MacGinnitie, Shrikant Anant, Nicholas O. Davidson — 1995
• Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif proteinAnn M. Sheehy, Nathan Gaddis, Jonathan Choi — 2002
• Functional characterization of human carbonic anhydrase II variants with altered zinc binding sites.Laura L. Kiefer, Carol A. Fierke — 1994
• The APOBEC-2 crystal structure and functional implications for the deaminase AIDCourtney Prochnow, Ronda Bransteitter, Michael G. Klein — 2007
• Flight of a cytidine deaminase complex with an imperfect transition state analogue inhibitor: mass spectrometric evidence for the presence of a trapped water molecule.Gottfried K. Schroeder, Li Zhou, Mark J. Snider — 2012
• Intracellular Localization of Human Cytidine DeaminaseAngelika Somasekaram, Adam Jarmuz, Alan How — 1999
• A functional single-nucleotide polymorphism in the human cytidine deaminase gene contributing to ara-C sensitivity.Li-Jie Yue, Yutaka Saikawa, Kazuhisa Ota — 2003
• Fourier transform ion cyclotron resonance MS reveals the presence of a water molecule in an enzyme transition-state analogue complex.Christoph H. Borchers, Víctor E. Márquez, Gottfried K. Schroeder — 2004
• Evolutionary origins of apoB mRNA editing: catalysis by a cytidine deaminase that has acquired a novel RNA-binding motif at its active site.Naveenan Navaratnam, Shoumo Bhattacharya, Takahlro Fujino — 1995
• Thiazole and oxazole peptides: biosynthesis and molecular machinery.Ranabir Sinha Roy, Amy M. Gehring, Jill C. Milne — 1999
• Major contribution of a carboxymethyl group to transition-state stabilization by cytidine deaminase: mutation and rescue.Dean C. Carlow, Albert A. Smith, Charles C. Yang — 1995
• An adenosine-to-inosine tRNA-editing enzyme that can perform C-to-U deamination of DNAMary Anne T. Rubio, Irena Pastar, Kirk W. Gaston — 2007
• Activity of Yeast Orotidine-5′-phosphate Decarboxylase in the Absence of Metals*Brian G. Miller, Jeffrey A. Smiley, Steven A. Short — 1999
• Escherichia coli cytosine deaminase: the kinetics and thermodynamics for binding of cytosine to the apoenzyme and the Zn(2+) holoenzyme are similar.David Porter — 2000

Related papers

• Advantages and Disadvantages of Cytidine Deamination1Marília Cascalho — 2004
• An Enzymatic Assay for High-Throughput Screening of Cytidine-Producing Microbial StrainsHuina Dong, Yongfei Liu, Xin Lin Zu — 2015
• Regulation of pyrimidine nucleotide biosynthesis in cytidine deaminase-negative mutants of Bacillus subtilisSatoru Asahi, Muneharu Doi, Yutaka Tsunemi — 1989
• Cytidine deaminase: a rapid method of purification and some properties of the enzyme from human placenta.Alberto Vita, Silvia Vincenzetti, Adolfo Amici — 1991
• A Quantum Chemical Study of the Catalysis for Cytidine Deaminase: Contribution of the Extra Water MoleculeToshiaki Matsubara, Masashi Ishikura, Misako Aida — 2006
• Knockout of the cdd Gene in Bacillus subtilis and its Influence on Cytidine FermentationXie Xi — 2010
• Biochemical and structural analysis of the Klebsiella pneumoniae cytidine deaminase CDA.Wei Liu, Fei Shang, Yuanyuan Chen — 2019