The three-dimensional structure of an eukaryotic glutamine synthetase: functional implications of its oligomeric structure.
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Summary
The structure of the prokaryotic glutamine synthetases type I and II, key enzymes in nitrogen metabolism, was determined several years ago by X-ray diffraction, and consists of a double hexameric ring, and the reconstructed tetramer suggests that it only contains two functional active sites.
- Type
- article
- Published
- 2006-12-01
- Cited by
- 66
- References
- 48
- OpenAlex
- https://openalex.org/W2001139474
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33144456
Keywords
Tetramer, Histone octamer, Dimer, Glutamine synthetase, Active site
References
- The purification and properties of the glutamine synthetase from the cytosol of Soya-bean root nodules.
- Glutamine Synthetase Isolated from Human Brain: Octameric Structure and Homology of Partial Primary Structure with Human Liver Glutamine Synthetase
- Analytical ultracentrifugation in biochemistry and polymer science
- Glutamine : metabolism, enzymology, and regulation
- Rat liver glutamine synthetase. Preparation, properties, and mechanism of inhibition by carbamyl phosphate.
- Multicopy crystallographic refinement of a relaxed glutamine synthetase from Mycobacterium tuberculosis highlights flexible loops in the enzymatic mechanism and its regulation.
- Structure-function relationships of glutamine synthetases.
- Novel subunit—subunit interactions in the structure of glutamine synthetase
- Structure Prediction and Active Site Analysis of the Metal Binding Determinants in γ-Glutamylcysteine Synthetase*
- Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases.
- Electron microscopy of multiple forms of glutamine synthetase from bacteroids and the cytosol of yellow lupin root nodules
- Molecular Identification and Characterization of Cytosolic Isoforms of Glutamine Synthetase in Maize Roots*
- Association-dissociation of mammalian brain glutamine synthetase: effects of metal ions and other ligands.
- ATP binding to purified homopolymeric plant glutamine synthetase studied by isothermal titration calorimetry
- EMAN: semiautomated software for high-resolution single-particle reconstructions.
- Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features
- Glutamine synthetases of pea leaf and seed cytosol. Structure and properties
- SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling
- Regulation of rat liver glutamine synthetase: activation by alpha-ketoglutarate and inhibition by glycine, alanine, and carbamyl phosphate.
- Glutamine synthetase isoenzymes, oligomers and subunits from hairy roots of Beta vulgaris L. var. lutea
Cited by
- Structure, Function and Regulation of Two Isoforms of Glutamine Synthetase from Soybean Root Nodules
- Critical Evaluation of the Changes in Glutamine Synthetase Activity in Models of Cerebral Stroke
- Understanding the gender-based mechanism of MSO treatment in ALS mice: A metabolic characterization of the SOD1-G93A mouse model
- New isoforms and assembly of glutamine synthetase in the leaf of wheat (Triticum aestivum L.)
- Epigenetic regulation of amino acids metabolic genes defines targets of synthetic lethality in breast cancer
- Cloning, expression and functional validation of drought inducible ascorbate peroxidase (Ec-apx1) from Eleusine coracana
- Crystal structure of Saccharomyces cerevisiae glutamine synthetase Gln1 suggests a nanotube‐like supramolecular assembly
- Comparative Protein Modeling, Prediction of Conserved Residue and Active Sites in Cold Resistant Protein Isolated from CRPF1, A Cold Tolerant Mutant of Pseudomonas fluorescens
- ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins
- Crystal structure of Type III glutamine synthetase: surprising reversal of the inter-ring interface.
- Recognition of Errors in the Refinement and Validation of Three-Dimensional Structures of AC1 Proteins of Begomovirus Strains by Using ProSA-Web
- Lengsin is a survivor of an ancient family of class I glutamine synthetases re-engineered by evolution for a role in the vertebrate lens.
- Cloning and characterization of the glutamine synthetase gene from Chinese shrimp Fenneropenaeus chinensis
- Crystallization and preliminary crystallographic characterization of glutamine synthetase from Medicago truncatula.
- Identification of an essential cysteinyl residue for the structure of glutamine synthetase α from Phaseolus vulgaris
- Amino acids in the second transmembrane helix of the Lhca4 subunit are important for formation of stable heterodimeric light-harvesting complex LHCI-730.
- A rapid method to improve protein detection by indirect ELISA.
- Validation of Arsenic Resistance in Bacillus cereus Strain AG27 by Comparative Protein Modeling of arsC Gene Product
- A nodulin/glutamine synthetase-like fusion protein is implicated in the regulation of root morphogenesis and in signalling triggered by flagellin
- Metabolic pathway compartmentalization: an underappreciated opportunity?
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