Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice.
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Summary
The findings suggest that TIM-1 may be a novel therapeutic target for modulating the immune response and provide insight into the signals involved in the generation and induction of Bregs.
- Type
- article
- Published
- 2011-09-01
- Cited by
- 473
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W2001101603
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26333668
Keywords
Regulatory B cells, Biology, Cell biology, Immune system, Immune tolerance
References
- Suppression of Proteoglycan-Induced Arthritis by Anti-CD20 B Cell Depletion Therapy Is Mediated by Reduction in Autoantibodies and CD4+ T Cell Reactivity1
- Intravenous Transfusion of BCR-Activated B Cells Protects NOD Mice from Type 1 Diabetes in an IL-10-Dependent Manner1
- Cutting Edge: The Development of IL-4-Producing B Cells (B Effector 2 Cells) Is Controlled by IL-4, IL-4 Receptor α, and Th2 Cells1
- Regulatory Role of B Cells in a Murine Model of Allergic Airway Disease1
- Reciprocal regulation of polarized cytokine production by effector B and T cells
- Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells.
- Regulatory B Cells Shape the Development of Th2 Immune Responses in BALB/c Mice Infected with Leishmania major Through IL-10 Production
- Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice
- Cutting Edge: Transplantation Tolerance through Enhanced CTLA-4 Expression 1
- Novel Suppressive Function of Transitional 2 B Cells in Experimental Arthritis1
- Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation.
- Regulatory function of CpG-activated B cells in late-phase experimental allergic conjunctivitis.
- Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells
- Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family
- Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice.
- TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells.
- The polymorphisms of Tim-1 promoter region are associated with rheumatoid arthritis in a Korean population
- TLR-9 Activation of Marginal Zone B Cells in Lupus Mice Regulates Immunity Through Increased IL-10 Production
- CD19 expression in B cells is important for suppression of contact hypersensitivity.
- B‐lymphocyte contributions to human autoimmune disease
Cited by
- Targeting TIM-1 on CD4 T Cells Depresses Macrophage Activation and Overcomes Ischemia-Reperfusion Injury in Mouse Orthotopic Liver Transplantation
- TIM-1 deficiency eliminates airway hyperreactivity triggered by the recognition of airway cell death
- KIM-1-mediated phagocytosis reduces acute injury to the kidney.
- The Role of KIM-1 Mediated Efferocytosis by Cancer Cells in Blocking the Immunogenicity of Tumor Cell Death
- Generation and identification of tumor-evoked regulatory B cells
- Regulation of extrafollicular immunoglobulin class switch recombination
- Interleukin-10-producing B cells and the regulation of immunity.
- Hematopoietic progenitor populations for cell therapy of autoimmune diseases : characterization and comparison of their mechanism of action in Type I Diabetes and Experimental Autoimmune Encephalomyelitis
- Killer B Cells: Regulation of the Growth and Function of Fas Ligand-Expressing B Lymphocytes.
- Étude des mécanismes impliqués dans la tolérance à l'allogreffe cardiaque chez le rat
- Characterization of Regulatory B Cells in Graves’ Disease and Hashimoto’s Thyroiditis
- Evidence for TLR4 and FcRγ-CARD9 activation by cholera toxin B subunit and its direct bindings to TREM2 and LMIR5 receptors.
- Regulatory B Cell Function Is Suppressed by Smoking and Obesity in H. pylori-Infected Subjects and Is Correlated with Elevated Risk of Gastric Cancer
- Interleukin-35: Expanding Its Job Profile
- Transitional‐2 B cells acquire regulatory function during tolerance induction and contribute to allograft survival
- THE EMERGING ROLE OF THE TIM MOLECULES IN TRANSPLANTATION
- B‐type suppression: A role played by “regulatory B cells” or “regulatory plasma cells”?
- Regulatory B cells correlate with HIV disease progression
- Multiple Mechanisms of Immune Suppression by B Lymphocytes
- Anti-CD45RB/anti-TIM-1-induced tolerance requires regulatory B cells
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