Transcriptional noise and the fidelity of initiation by RNA polymerase II
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Summary
It is suggested that 90% of Pol II initiation events in yeast represent transcriptional noise, and that the specificity of initiation is comparable to that of DNA-binding proteins and other biological processes.
- Type
- article
- Published
- 2007-02-01
- Cited by
- 665
- References
- 25
- OpenAlex
- https://openalex.org/W2000629769
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29398526
Keywords
RNA polymerase II, Biology, Transcription (linguistics), Genetics, Computational biology
References
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- Enhancement of TBP binding by activators and general transcription factors
- Evidence for a mediator cycle at the initiation of transcription.
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- RNA degradation by the exosome is promoted by a nuclear polyadenylation complex.
- Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation.
- The Rtf1 Component of the Paf1 Transcriptional Elongation Complex Is Required for Ubiquitination of Histone H2B*
- Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylation.
- Nucleosome displacement in transcription.
- Quantitation of the RNA Polymerase II Transcription Machinery in Yeast*
- Noise in Gene Expression: Origins, Consequences, and Control
- The economics of ribosome biosynthesis in yeast.
- Intrinsic histone-DNA interactions and low nucleosome density are important for preferential accessibility of promoter regions in yeast.
- Genome-wide distribution of yeast RNA polymerase II and its control by Sen1 helicase.
- Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo.
- The Transcriptional Landscape of the Mammalian Genome
- Absolute mRNA levels and transcriptional initiation rates in Saccharomyces cerevisiae.
- Genome-Scale Identification of Nucleosome Positions in S. cerevisiae
- TUF love for "junk" DNA.
- A high-resolution map of transcription in the yeast genome.
Cited by
- Regulation of Adipocyte Transcription by PPARgamma Ligands
- A canonical promoter organization of the transcription machinery and its regulators in the Saccharomyces genome
- Untargeted tail acetylation of histones in chromatin: lessons from yeast.
- Identification of sense and antisense transcripts regulated by drought in sugarcane
- DNA methylation and transcriptional noise
- Non-coding RNAs and the borders of heterochromatin
- Budding yeast chromatin is dispersed in a crowded nucleoplasm in vivo
- New Frontiers of Network Analysis in Systems Biology
- Characterisation in mice of a conserved sequence, Mcr2, associated with the Wilms' tumour 1 (Wt1) locus
- Non-coding RNAs of the bithorax complex in the developing Drosophila embryo
- IDENTIFICATION AND CHARACTERIZATION OF FACTORS REQUIRED FOR REPRESSION OF THE YEAST SER3 GENE BY SRG1 INTERGENIC TRANSCRIPTION
- Long noncoding RNAs: implications for antigen receptor diversification.
- Bioinformatics analysis of ZBED6, a noveltranscription factor in mammals
- Expression of long noncoding RNA-HOX transcript antisense intergenic RNA in oral squamous cell carcinoma and effect on cell growth
- Micropeptides as non-classical bioactive peptides in Eukaryotes, a ribosome profiling centered approach
- Investigation of a developmentally linked transcriptional gene silencing mechanism involving an antisense RNA
- Transcriptomic basis of post-mating responses in females of the parasitic wasp Nasonia vitripennis
- Differential lncRNA expression profiles in recurrent gliomas compared with primary gliomas identified by microarray analysis.
- The code of noncoding RNAs in lung fibrosis
- TFIIS-Dependent Non-coding Transcription Regulates Developmental Genome Rearrangements
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