Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single‐cell level
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Summary
The characterization of seven anti‐FOXP3 monoclonal antibodies enabling the detection of endogenous human FOXP3 protein by flow cytometry and immunohistochemistry indicate that the frequency ofFOXP3+ cells correlates with the level of expression of CD25 in naturally arising regulatory T cells and that FOXP 3 protein is expressed by some activated CD4+ and CD8+ T cell clones.
- Type
- article
- Published
- 2005-06-01
- Cited by
- 450
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W1998350666
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45075720
Keywords
FOXP3, IL-2 receptor, Biology, Flow cytometry, Regulatory T cell
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- JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome.
- Letter: Training in family planning.
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- Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT3 and ILT4
- Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans.
- A pathogenetic role for the thymoma in myasthenia gravis. Autosensitization of IL-4- producing T cell clones recognizing extracellular acetylcholine receptor epitopes presented by minority class II isotypes.
- Immunocytochemical detection of T and B cell populations in routine blood smears.
- Frontline: Neuropilin‐1: a surface marker of regulatory T cells
Cited by
- Regulatory T-cells, FoxP3 and atherosclerosis.
- Photoimmunology and Multiple Sclerosis.
- CD4+CD25high T Cells Are Enriched in the Tumor and Peripheral Blood of Prostate Cancer Patients1
- Minimal change nephrotic syndrome associated with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome
- Disturbed regulatory T cell homeostasis in multiple sclerosis.
- Efficient peripheral construction of functional human regulatory CD4(+)CD25(high)Foxp3(+) T cells in NOD/SCID mice grafted with fetal human thymus/liver tissues and CD34(+) cells.
- CD4+CD62L+ Central Memory T Cells Can Be Converted to Foxp3+ T Cells
- Biology and clinical observations of regulatory T cells in cancer immunology.
- CD4+ T-Zell-vermittelte Immunregulation während der Plasmodium yoelii-Infektion
- Lower percentages of T regulatory cells in children with type 1 diabetes - preliminary report.
- Pathology of T-cell lymphomas: diagnosis and biomarker discovery.
- Role of Melanoma Secreted Thrombospondin-1 on Induction of Immunosuppressive Regulatory T Cells through CD47
- Human CD4+CD25(high)CD127 (low/neg) regulatory T cells.
- Diagnóstico Molecular y Genético de Inmunodeficiencias Primarias ligadas al X
- Etude des mécanismes de régulation après injection de cellules dendritiques allogéniques OX62+ associées à un anticorps anti-CD4 non déplétant dans un modèle de rejet chronique chez le rat
- The role of regulatory T cells in primary infection with Epstein-Barr virus
- T cell subsets and the outcome of haematopoietic stem cell transplantation
- Study of immunomics and immune regulation in ovarian cancer
- Increased regulatory T‐cell frequencies in patients with advanced melanoma correlate with a generally impaired T‐cell responsiveness and are restored after dendritic cell‐based vaccination
- The human T cell response to melanoma antigens.
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