S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast
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Summary
Sld2, one of the replication proteins of budding yeast, is phosphorylated in S phase in an S-Cdk-dependent manner, and mutant Sld2 lacking all the preferred Cdk phosphorylation sites (All-A) is defective in chromosomal DNA replication.
- Type
- article
- Published
- 2002-02-07
- Cited by
- 242
- References
- 30
- OpenAlex
- https://openalex.org/W1992334813
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4300863
Keywords
Budding yeast, Cell biology, DNA replication, Control of chromosome duplication, DNA re-replication
References
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- Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.
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- Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase.
- ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex
- At the heart of the budding yeast cell cycle.
- A long twentieth century of the cell cycle and beyond.
- The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae.
- Multifunctional yeast high-copy-number shuttle vectors.
Cited by
- DNA replication initiation.
- The initiation step of eukaryotic DNA replication.
- Control of Mus81 nuclease during the cell cycle
- Functional and structural properties of eukaryotic DNA polymerase epsilon
- Regulation of genome stability via Mcm2-7 ATPase active sites in Saccharomyces cerevisiae
- The role of the Mcm2 subunit in regulating the activities of the Mcm2-7 helicase
- The N-terminal region of RECQL4 lacking the helicase domain is both essential and sufficient for the viability of vertebrate cells. Role of the N-terminal region of RECQL4 in cells.
- The GINS complex: structure and function.
- Control of DNA replication by cyclin-dependent kinases in development.
- Initiation of DNA replication in Xenopus egg extracts.
- DNA replication and genomic instability.
- The Regulated Loading and Distribution of the Mcm2-7 Helicase During G1
- Cell cycle-dependent modification of Pot1 and its effects on telomere function
- Rôle de la protéine Cdk5 en réponse aux dommages de l’ADN : implications dans les points de contrôle S et G2/M
- The Eukaryotic Replisome: a Guide to Protein Structure and Function
- The role of protein kinases in DNA replication in Saccharomyces cerevisiae
- Exploring the roles and mechanisms of CDC18 in the cell cycle of fission yeast.
- Multiple, nutrient sensing kinases converge to phosphorylate an element of Cdc34 that increases Saccharomyces cerevisiae lifespan
- Characterisation of fission yeast DNA replication origins.
- The role of Cdc7 and cyclin-dependent kinases in DNA replication and S phase
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