An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
Explore this paper's citation graph
Summary
Evidence is provided for a previously unidentified pathophysiological function of the AHR that is constitutively generated by human tumours via tryptophan-2,3-dioxygenase (TDO), a liver- and neuron-derived Trp-degrading enzyme not yet implicated in cancer biology.
- Type
- article
- Published
- 2011-10-13
- Cited by
- 1,802
- References
- 33
- Access
- Open access
- OpenAlex
- https://openalex.org/W1998142996
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4314650
Keywords
Aryl hydrocarbon receptor, Autocrine signalling, Kynurenine, Paracrine signalling, Biology
References
- A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors
- Tryptophan-derived Catabolites Are Responsible for Inhibition of T and Natural Killer Cell Proliferation Induced by Indoleamine 2,3-Dioxygenase
- AN INTERACTION BETWEEN KYNURENINE AND THE ARYL HYDROCARBON RECEPTOR CAN GENERATE REGULATORY T CELLS,
- Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.
- Inflammation and cancer
- Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
- The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers.
- Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor
- Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase
- The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
- Indoleamine 2,3-dioxygenase and tumor-induced tolerance.
- Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor
- Comprehensive genomic characterization defines human glioblastoma genes and core pathways
- Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.
- Promoter analysis of TCDD-inducible genes in a thymic epithelial cell line indicates the potential for cell-specific transcription factor crosstalk in the AhR response.
- The Indoleamine-2,3-Dioxygenase (IDO) Inhibitor 1-Methyl-D-tryptophan Upregulates IDO1 in Human Cancer Cells
- Aryl hydrocarbon receptor inhibition downregulates the TGF-β/Smad pathway in human glioblastoma cells
- Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees?
- Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice.
- Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism
Cited by
- Different Partners, Opposite Outcomes: A New Perspective of the Immunobiology of Indoleamine 2,3-Dioxygenase
- Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and periphery
- The kynurenine pathway in brain tumor pathogenesis.
- Subpathway-GM: identification of metabolic subpathways via joint power of interesting genes and metabolites and their topologies within pathways
- Review of mass spectrometry-based metabolomics in cancer research
- Metabolomic Analysis of Clinical Plasma from Cerebral Infarction Patients Presenting with Blood Stasis
- An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells
- LC-MS/MS-based quantification of kynurenine metabolites, tryptophan, monoamines and neopterin in plasma, cerebrospinal fluid and brain.
- A short history of heme dioxygenases: rise, fall and rise again
- Urinary profiling of tryptophan and its related metabolites in patients with metabolic syndrome by liquid chromatography-electrospray ionization/mass spectrometry
- Targeting the IDO1 pathway in cancer: from bench to bedside
- Lactobacillus maintains healthy gut mucosa by producing L-Ornithine
- Physical Exercise as Kynurenine Pathway Modulator in Chronic Diseases: Implications for Immune and Energy Homeostasis
- Tumor dormancy: long-term survival in a hostile environment.
- Transcription factors controlling innate lymphoid cell fate decisions.
- Indoleamine 2,3-dioxygenase confers resistance to chemotherapy and γ radiation to cancer cells, independent of direct immune involvement
- Inflammation-related disorders in the tryptophan catabolite pathway in depression and somatization.
- Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells
- Les toxines urémiques provoquent un phénotype procoagulant de l'endothelium par la voie du facteur de transcription AHR
- Levels in neurotransmitter precursor amino acids correlate with mental health in patients with breast cancer.
Related papers
- Computational model and microfluidic platform for the investigation of paracrine and autocrine signaling in mouse embryonic stem cells
- Renal autocrine and paracrine signaling -a story of self-protection.
- Autocrine/paracrine function of parathyroid hormone-related peptide in rat osteoblast-like cells.
- The possible role of IL—1 autocrine and paracrine in mesangial cell(MSc)
- Cellular Fate Decision by Autocrine and Paracrine in Tumor
- Autocrine/paracrine involvement of insulin‐like growth factor‐I and its receptor in chronic lymphocytic leukaemia
- Stromal Cell-Derived Factor-1a Autocrine/Paracrine Signaling Contributes to Spatiotemporal Gradients in the Brain
- Autocrine and paracrine growth inhibitors of breast cancer cells