Presence of reactive microglia in monkey substantia nigra years after 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine administration
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Summary
Evidence of chronic neuroinflammation years after MPTP exposure is similar to that previously reported in humans and could have important implications regarding the cause of Parkinson's disease and possible approaches to therapy.
- Type
- article
- Published
- 2003-11-01
- Cited by
- 426
- References
- 35
- OpenAlex
- https://openalex.org/W1997124326
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:43815295
Keywords
MPTP, Substantia nigra, Microglia, Dopaminergic, Neuroinflammation
References
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- Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in parkinson's disease
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- Neurofibrillary tangles of Guam parkinson-dementia are associated with reactive microglia and complement proteins.
- The High Sensitivity to Rotenone of Striatal Dopamine Uptake Suggests the Existence of a Constitutive Metabolic Deficiency in Dopaminergic Neurons From the Substantia Nigra
- Reduced incidence of AD with NSAID but not H2 receptor antagonists: The Cache County Study
- Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine exposure
- 1-Methyl-4-phenylpyridinium ion (MPP+): identification of a metabolite of MPTP, a toxin selective to the substantia nigra.
- Mitochondrial Complex I Deficiency in Parkinson's Disease
Cited by
- Interleukin-18 null mice show diminished microglial activation and reduced dopaminergic neuron loss following acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment.
- Role of complement in neurodegeneration and neuroinflammation.
- Nigrostriatal Dopaminergic Neurodegeneration in the Weaver Mouse Is Mediated via Neuroinflammation and Alleviated by Minocycline Administration
- Astrocyte–neuron interactions in neurological disorders
- Mesenchymal stem cell transplantation attenuates blood brain barrier damage and neuroinflammation and protects dopaminergic neurons against MPTP toxicity in the substantia nigra in a model of Parkinson's disease.
- The Involvement of Neuroinflammation and Kynurenine Pathway in Parkinson's Disease
- Increased tyrosine hydroxylase expression accompanied by glial changes within the non-lesioned hemisphere in the 6-hydroxydopamine model of Parkinson's disease
- Innate Immunity and Inflammation Post-Stroke: An α7-Nicotinic Agonist Perspective
- Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects.
- Microglial cells in neurodegenerative disorders.
- RESTORATION OF MOTOR AND NON-MOTOR FUNCTIONS BY NEUROTROPHIC FACTORS IN NONHUMAN PRIMATES WITH DOPAMINE DEPLETION
- Role of the prolyl isomerase Pin1 in the pathogenesis of Parkinson's disease and neuroprotection by novel targeted compounds in pre-clinical animal models of the disease
- De la stimulation cérébrale profonde à l’étude physiopathologique de certaines formes génétiques de la Maladie de Parkinson
- Molecular imaging and the neuropathologies of Parkinson's disease.
- AMPHETAMINE-INDUCED DOPAMINERGIC TOXICITY: A SINGLE DOSE ANIMAL MODEL OF PARKINSON'S DISEASE
- Place de l'activation microgliale associée à la dégénérescence des neurones dopaminergiques provoquée par la 6-OHDA chez le rat : implication dans la compréhension de la pathogénie de la maladie de Parkinson
- Anestesia in corso di tomografia ad emissione di positroni (PET) in primati non umani come modello sperimentale della malattia di Parkinson
- ROLES OF CYCLOOXYGENASE-2 IN MICROGLIAL ACTIVATION AND DOPAMINERGIC CELL DEATH
- The Effect of Acute LPS-Induced Immune Activation and Brain Insulin Signaling Disruption in a Diabetic Model of Alzheimer's Disease
- Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy?
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