Synonymous and nonsynonymous substitutions in mammalian genes and the nearly neutral theory
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Summary
The rate and pattern found here are consistent with the nearly neutral theory, such that the relative contributions of drift and selection differ between the two types of substitutions, and are also consistent with Gillespie's episodic selection theory.
- Type
- article
- Published
- 2004-01-01
- Cited by
- 132
- References
- 32
- OpenAlex
- https://openalex.org/W1997012028
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6187676
Keywords
Nonsynonymous substitution, Biology, Synonymous substitution, Neutral theory of molecular evolution, Negative selection
References
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- An examination of the generation-time effect on molecular evolution.
- Slightly Deleterious Mutant Substitutions in Evolution
- The human growth hormone locus: nucleotide sequence, biology, and evolution.
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- The neutral theory of molecular evolution.
- Mammalian gene evolution: Nucleotide sequence divergence between mouse and rat
- The pattern of mammalian evolution and the relative rate of molecular evolution.
- The mosaic genome of warm-blooded vertebrates.
Cited by
- Quantitative estimates of sequence divergence for comparative analyses of mammalian genomes.
- Nearly Neutral Evolution Across the Drosophila melanogaster Genome
- Estimation des corrélations phylogénétiques entre paramètres d'évolution moléculaire et Traits d'histoire de vie
- Genome evolution and speciation : insights from cichlid, coelacanth, and Xiphophorus fish
- JOINT RECONSTRUCTION OF DIVERGENCE TIMES AND LIFE‐HISTORY EVOLUTION IN PLACENTAL MAMMALS USING A PHYLOGENETIC COVARIANCE MODEL
- Mutation and selection at silent and replacement sites in the evolution of animal mitochondrial DNA
- Purifying selection in mitochondria, free-living and obligate intracellular proteobacteria
- Evolution by nearly-neutral mutations
- Deleterious mutation accumulation in organelle genomes
- Pigs in sequence space: A 0.66X coverage pig genome survey based on shotgun sequencing
- Initial sequence of the chimpanzee genome and comparison with the human genome
- Comparative analysis of protein coding sequences from human, mouse and the domesticated pig
- Endosymbiont evolution: Predictions from theory and surprises from genomes
- Pervasive Cryptic Epistasis in Molecular Evolution
- Molecular Characterization of Repetitive DNA Sequences from B Chromosome in Plantago lagopus L.
- Natural selection on gene expression.
- Testing the neutral theory of molecular evolution with genomic data from Drosophila
- Extreme difference in rate of mitochondrial and nuclear DNA evolution in a large ectotherm, Galápagos tortoises.
- Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates
- Size of the protein-coding genome and rate of molecular evolution
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