Genetic origin of mutations predisposing to retinoblastoma.
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Summary
A new approach for identifying recessive mutant genes that lead to cancer and a conceptual basis for accurate prenatal predictions of cancer predisposition are suggested.
- Type
- article
- Published
- 1985-04-26
- Cited by
- 345
- References
- 13
- OpenAlex
- https://openalex.org/W1995822744
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9108264
Keywords
Retinoblastoma, Genetics, Biology, Germline, Locus (genetics)
References
- Patient with 13 chromosome deletion: evidence that the retinoblastoma gene is a recessive cancer gene.
- Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma.
- Development of homozygosity for chromosome 11p markers in Wilms' tumour
- Gene for hereditary retinoblastoma assigned to human chromosome 13 by linkage to esterase D.
- Expression of recessive alleles by chromosomal mechanisms in retinoblastoma
- Regional assignment of genes for human esterase D and retinoblastoma to chromosome band 13q14.
- Abnormalities of chromosome #13 in retinoblastomas from individuals with normal constitutional karyotypes.
- Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour
- Loss of a Harvey ras allele in sporadic Wilms' tumour
- Mutation and cancer: statistical study of retinoblastoma.
- Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours
- Familial retinoblastoma and chromosome 13 deletion transmitted via an insertional translocation.
- Isolation and regional localization of DNA segments revealing polymorphic loci from human chromosome 13.
Cited by
- Clonal origins of adrenocorticotropin-secreting pituitary tissue in Cushing's disease.
- The genetics of retinoblastoma.
- Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors.
- Anti-oncogenes. A subset of regulatory genes involved in carcinogenesis?
- Heterogeneity of genetic alterations in primary human breast tumors.
- Suppression of the neoplastic phenotype and “anti-oncogenes”
- Knudson to embryo selection: A story of the genetics of retinoblastoma
- From chimney sweeps to astronauts: cancer risks in the work place: the 1998 Lauriston Taylor lecture.
- Environmental causes of cancer.
- Induction of programmed cell death in human retinoblastoma Y79 cells by C2-ceramide
- ANALYSIS OF THE AMINO-TERMINAL DOMAIN OF DROSOPHILA RBF1 INDICATES NOVEL ROLES IN CELL REGULATION
- Duplication and loss of chromosome 21 in two children with Down syndrome and acute leukemia.
- "Genome-wide analysis of miRNA gene methylation in non-small cell lung cancer patients"
- Recessive mutations in cancer predisposition and progression.
- Genetic mechanisms of tumor-specific loss of 11p DNA sequences in Wilms tumor.
- Oncogenes in human solid tumors.
- Genotype-phenotype correlation analysis in retinoblastoma patients from India.
- Genomic changes in glioblastoma cell lines detected by comparative genomic hybridization
- Search for the gene for multiple endocrine neoplasia type 2A.
- Cancer models: A nonhomogeneous two-stage model of carcinogenesis
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