Mutation and cancer: statistical study of retinoblastoma.
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Summary
The hypothesis is developed that retinoblastoma is a cancer caused by two mutational events, in the dominantly inherited form, one mutation is inherited via the germinal cells and the second occurs in somatic cells.
- Type
- article
- Published
- 1971-04-01
- Cited by
- 7,653
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W2077858999
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28603369
Keywords
Retinoblastoma, Mutation rate, Mutation, Germline mutation, Somatic cell
References
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