Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.
Explore this paper's citation graph
Summary
Results indicate that phosphorylation of LIM-kinase by ROCK and consequently increased phosphorylated of cofilin by LIM- Kinase contribute to Rho-induced reorganization of the actin cytoskeleton.
- Type
- article
- Published
- 1999-08-06
- Cited by
- 1,736
- References
- 19
- OpenAlex
- https://openalex.org/W1995757732
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:746695
Keywords
Cofilin, Cell biology, Rho-associated protein kinase, PAK1, Phosphorylation
References
- Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
- Characterization of a novel cofilin isoform that is predominantly expressed in mammalian skeletal muscle.
- Cofilin promotes rapid actin filament turnover in vivo
- Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
- Phosphorylation of Ser‐3 of cofilin regulates its essential function on actin
- Actin dynamics in vivo.
- Inhibition of myosin light chain kinase by p21-activated kinase.
- Reactivation of Phosphorylated Actin Depolymerizing Factor and Identification of the Regulatory Site (*)
- Isolation and characterization of a regulated form of actin depolymerizing factor
- Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)
- Identification and Characterization of a Novel Family of Serine/Threonine Kinases Containing Two N-terminal LIM Motifs (*)
- The small GTPase Rho: cellular functions and signal transduction.
- Focal adhesion assembly.
- The ADF/cofilin proteins: stimulus-responsive modulators of actin dynamics.
- Rho GTPases and the actin cytoskeleton.
- Regulation of the Association of Adducin with Actin Filaments by Rho-associated Kinase (Rho-kinase) and Myosin Phosphatase*
- Rho-Kinase Phosphorylates COOH-terminal Threonines of Ezrin/Radixin/Moesin (ERM) Proteins and Regulates Their Head-to-Tail Association
Cited by
- Structural Insights into the Shroom-Rock Interaction and the Regulation of the Actomyosin Cytoskeleton
- Phospholipase D, perméabilité endothéliale, et apoptose TNFα dépendante
- Potential Role of Microsomal Prostaglandin E Synthase-1 in Tumorigenesis*
- A memory GAP.
- Phosphatidylinositol Phosphate Kinases Put PI4,5P2 in Its Place
- Signaling mechanisms utilized by antigen receptors and integrins: common intermediates, different outcomes?
- LIM kinases: function, regulation and association with human disease
- The Regulation of Dendritic Spine Plasticity by EphB and N-methyl-D-aspartate Receptors Through Spatial Control Over Cofilin Activity in Mature Hippocampal Neurons
- Genetic Factors for Ischemic and Hemorrhagic Stroke in Japanese Individuals
- Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts.
- The ADF/Cofilin-Pathway and Actin Dynamics in Podocyte Injury
- Loss of PTEN induces microtentacles through PI3K-independent activation of cofilin
- β‐Arrestin‐kinase scaffolds: turn them on or turn them off?
- β-Arrestin–Dependent Activation of the Cofilin Pathway Is Required for the Scavenging Activity of the Atypical Chemokine Receptor D6
- Multi-level control of actin dynamics by protein kinase D.
- Regulation of RhoA Activation and Actin Reorganization by Diacylglycerol Kinase
- ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS
- Mechanobiological Feedback in Pulmonary Vascular Disease
- Role of nuclear mechanosensitivity in determining cellular responses to forces and biomaterials.
- The role of mevalonate pathway intermediates in erythropoietin receptor signal transduction and surface expression: Studies in hematopoietic and non-hematopoietic cancers
Related papers
- Effects of PAK1/LIMK1/Cofilin-mediated actin homeostasis on axonal injury after experimental intracerebral hemorrhage.
- The ROCK signaling regulates the pulmonary vascular permeability via maintenance of lung homeostasis.
- Rho-kinase: important new therapeutic target in cardiovascular diseases.
- RhoA/Rho-Kinase in the Cardiovascular System.
- Essential role of CIB1 in regulating PAK1 activation and cell migration
- Physiological role of ROCKs in the cardiovascular system.
- Rho kinase as a therapeutic target in cardiovascular disease
- RhoA/Rho-kinase and vascular diseases: what is the link?