Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts.
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Summary
It is demonstrated that Rock potently stimulates the differentiation of resting fibroblasts into myofibroblast and the production of ECM at biologically relevant concentrations without cell toxicity, indicating that inhibition of Rock might be an interesting novel therapeutic approach for the treatment of SSc.
- Type
- article
- Published
- 2008-08-01
- Cited by
- 125
- References
- 41
- OpenAlex
- https://openalex.org/W18668558
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8858410
Keywords
Humanities, Art
References
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- Megakaryoblastic leukemia-1 is required for the development of bleomycin-induced pulmonary fibrosis
- Fibroblast growth factor receptor 3 activates a network of profibrotic signaling pathways to promote fibrosis in systemic sclerosis
- Implications de la voie RhoA/Rho-kinases dans la physiopathologie des atteintes vasculaires et interstitielles pulmonaires des maladies respiratoires chroniques : études humaines et expérimentales chez la souris
- New insights into the mechanism of fibroblast to myofibroblast transformation and associated pathologies.
- Wound healing signals mediated by Rho/ROCK activation in response to radiotherapy and consequences fot treatmeny of late damage within normal tissues
- Chemotherapeutic Targeting of Fibulin-5 to Suppress Breast Cancer Invasion and Metastasis Stimulated by Transforming Growth Factor-Beta
- Fibrosis—a lethal component of systemic sclerosis
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- Key Fibrogenic Signaling
- Inhibition of glycogen synthase kinase 3β induces dermal fibrosis by activation of the canonical Wnt pathway
- Human lung parenchyma but not proximal bronchi produces fibroblasts with enhanced TGF-beta signaling and alpha-SMA expression.
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