Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts.

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Summary

It is demonstrated that Rock potently stimulates the differentiation of resting fibroblasts into myofibroblast and the production of ECM at biologically relevant concentrations without cell toxicity, indicating that inhibition of Rock might be an interesting novel therapeutic approach for the treatment of SSc.

Type
article
Published
2008-08-01
Cited by
125
References
41

Keywords

Humanities, Art

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