Change in Hexose Distribution Volume and Fractional Utilization of [18F]-2-Deoxy-2-Fluoro-D-Glucose in Brain During Acute Hypoglycemia in Humans
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Summary
In the presence of mild hypoglycemia, the brain extracts an increased fraction of 2-DFG from the blood and the constant rate of cerebral glucose metabolism suggests that this enhanced glucose uptake protects the brain from acute reductions in plasma glucose.
- Type
- article
- Published
- 1990-02-01
- Cited by
- 26
- References
- 41
- OpenAlex
- https://openalex.org/W1995585297
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39041089
Keywords
Endocrinology, Hypoglycemia, Internal medicine, Insulin, Glucose clamp technique
References
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- INSULIN AND THE WAY THE BRAIN HANDLES GLUCOSE 1
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- PETT VI: A Positron Emission Tomograph Utilizing Cesium Fluoride Scintillation Detectors
- Insulin increases glucose transfer across the blood-brain barrier in man.
- Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic Rats
- Cerebral glucose transport and oxygen consumption in sheep and rabbits
- The Interaction of Transport and Metabolism on Brain Glucose Utilization: A Reevaluation of the Lumped Constant
- Effects of Temporal Sampling, Glucose Metabolic Rates, and Disruptions of the Blood—Brain Barrier on the FDG Model with and without a Vascular Compartment: Studies in Human Brain Tumors with PET
- The influence of insulin upon the metabolism of glucose by the brain
- Tomographic measurement of local cerebral glucose metabolic rate in humans with (F‐18)2‐fluoro‐2‐deoxy‐D‐glucose: Validation of method
- THE [14C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1
- Autoradiographic Determination of Regional Brain Glucose Content
Cited by
- Metabolism of glucose in the brain of IDDM subjects: brain metabolism in diabetes.
- At the centennial of Michaelis and Menten, competing Michaelis-Menten steps explain effect of GLP-1 on blood-brain transfer and metabolism of glucose.
- Facilitated transport of glucose from blood to brain in man and the effect of moderate hypoglycaemia on cerebral glucose utilization
- Computer simulations suggest that acute correction of hyperglycaemia with an insulin bolus protocol might be useful in brain FDG PET
- Increase in glucose transporter densities of Glut3 and decrease of glucose utilization in rat brain after one week of hypoglycemia.
- Effects of previous glycaemic control on the onset and magnitude of cognitive dysfunction during hypoglycaemia in Type 1 (insulin-dependent) diabetic patients
- Does Tight Glucose Control Enhance Brain Sensitivity to Low Glucose?
- Vascular endothelial growth factor: a novel endocrine defensive response to hypoglycemia.
- Brain glucose metabolism in noninsulin-dependent diabetes mellitus: a study in Pima Indians using positron emission tomography during hyperinsulinemia with euglycemic glucose clamp.
- Quantitative PET for assessment of cerebral blood flow and glucose consumption under varying physiological conditions
- A possible mechanism for increased cerebrovascular permeability in diabetic rats: effects of insulin and 2-deoxy-glucose.
- Glucagon-Like Peptide-1 Decreases Intracerebral Glucose Content by Activating Hexokinase and Changing Glucose Clearance during Hyperglycemia
- Cognitive function in patients with insulin-dependent diabetes mellitus during hyperglycemia and hypoglycemia.
- Effects of Insulin on Brain Glucose Metabolism in Impaired Glucose Tolerance
- Importance of Insulin in Subjective, Cognitive, and Hormonal Responses to Hypoglycemia in Patients With IDDM
- Oxidized Low Density Lipoproteins: a Role in the Pathogenesis of Atherosclerosis in Diabetes?
- Changes in Brainstem Auditory Evoked Potentials During Insulin‐induced Hypoglycaemia in Type 1 Diabetic Patients
- Changes in regional brain (18)F-fluorodeoxyglucose uptake at hypoglycemia in type 1 diabetic men associated with hypoglycemia unawareness and counter-regulatory failure.
- Influence of diabetes mellitus on regional cerebral glucose metabolism and regional cerebral blood flow
- Cerebral energy metabolism, glucose transport and blood flow: changes with maturation and adaptation to hypoglycaemia.
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