Hyperinsulinemia suppresses glucose utilization in specific brain regions: in vivo studies using the euglycemic clamp in the rat.
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Summary
Reduced glucose utilization in specific brain regions in the presence of insulin levels both equal to and above those found in the postabsorptive state are revealed and support a direct effect of insulin in suppressing regional brain glucose utilization.
- Type
- article
- Published
- 1985-02-01
- Cited by
- 73
- References
- 46
- OpenAlex
- https://openalex.org/W1989284487
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19658295
Keywords
Internal medicine, Endocrinology, Insulin, Liter, Hyperinsulinemia
References
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- Stimulation of Counterregulatory Hormonal Responses in Diabetic Man by a Fall in Glucose Concentration
- Localization of CNS glucoregulatory insulin receptors within the ventromedial hypothalamus.
- Transport of glucose across the blood-brain barrier: reevaluation of the accelerative exchange diffusion.
- Catencholamine neuron systems in brain
Cited by
- Polycystic Ovary Syndrome, Insulin Resistance, and Obesity: Navigating the Pathophysiologic Labyrinth
- Insulin, synaptic function, and opportunities for neuroprotection.
- The Comparative Physiology of the Pancreatic Islets
- Role of Estrogens in Peripheral and Cerebral Glucose Utilization
- Rapid bidirectional effects of insulin on hypothalamic noradrenergic and serotoninergic neuronal activity in the rat: role in glucose homeostasis.
- Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects.
- A Neuroimmunological Model of Schizophrenia and Major Depression: A Review
- Effects of insulin and 2-deoxy-D-glucose administration on CNS IGF-II content.
- Effects of physiological manipulations on locus coeruleus neuronal activity in freely moving cats. I. Thermoregulatory challenge.
- Relationship between hypothalamic noradrenergic neuronal activity and serum 3-methoxy-4-hydroxyphenylethylene glycol in the rat.
- Effects of hyperinsulinemia on local cerebral insulin binding and glucose utilization in normoglycemic awake rats.
- Evidence for Effects of Insulin on Sensory Processing in Humans
- Change in Hexose Distribution Volume and Fractional Utilization of [18F]-2-Deoxy-2-Fluoro-D-Glucose in Brain During Acute Hypoglycemia in Humans
- The Effects of Differing Insulin Levels on the Hormonal and Metabolic Response to Equivalent Hypoglycemia in Normal Humans
- Elevated blood glucose is associated with poor outcome in the carbon-monoxide-poisoned rat.
- Supraphysiological hyperinsulinemia acutely increases hypothalamic-pituitary-adrenal secretory activity in humans.
- Acute severe carbon monoxide exposure in the rat: effects of hyperglycemia and hypoglycemia on mortality, recovery, and neurologic deficit.
- Insulin and related growth factors: effects on the nervous system and mechanism for neurite growth and regeneration.
- Effects of Insulin on Local Cerebral Glucose Utilization in the Rat
- The role of glucose, insulin and glucagon in the regulation of food intake and body weight.
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