EGF–ERBB signalling: towards the systems level
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Summary
It is useful to envision ERBB signalling as a bow-tie-configured, evolvable network, which shares modularity, redundancy and control circuits with robust biological and engineered systems.
- Type
- review
- Published
- 2006-07-01
- Cited by
- 2,073
- References
- 145
- OpenAlex
- https://openalex.org/W1995242599
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22086516
Keywords
Signalling, ErbB, Robustness (evolution), Systems biology, Signalling pathways
References
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- Tumor necrosis factor-alpha-stimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts.
- Lessons learnt from gefitinib and erlotinib: Key insights into small-molecule EGFR-targeted kinase inhibitors in non-small cell lung cancer.
- Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients
- Cancer Therapy Targeting the HER2-PI3K Pathway: Potential Impact on the Heart
- Differential Regulation of Transcription Factors by Location-Specific EGF Receptor Signaling via a Spatio-Temporal Interplay of ERK Activation
- Cetuximab-mediated tumor regression depends on innate and adaptive immune responses.
- Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells.
- The Effects of Neuregulin on Cardiac Myosin Light Chain Kinase Gene-Ablated Hearts
- The Extraction of Simple Relationships in Growth Factor-Specific Multiple-Input and Multiple-Output Systems in Cell-Fate Decisions by Backward Elimination PLS Regression
- Positional Isomerization of A Non‐Cleavable Combi‐Molecule Dramatically Altered Tumor Cell Response Profile
- FOXC1 is a critical mediator of EGFR function in human basal-like breast cancer
- Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation
- Dimerization drives EGFR endocytosis through two sets of compatible endocytic codes
- Molecular architecture of the ErbB2 extracellular domain homodimer
- Management of EGFR mutated nonsmall cell lung carcinoma patients
- A Phase II Biomarker-Embedded Study of Lapatinib plus Capecitabine as First-line Therapy in Patients with Advanced or Metastatic Gastric Cancer
- Current targeted therapies in the treatment of advanced colorectal cancer: a review
- Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases*
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