Serum Amyloid A Induces Lipolysis by Downregulating Perilipin Through ERK1/2 and PKA Signaling Pathways
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Summary
It is demonstrated that SAA‐induced lipolysis is a result of downregulation of perilipin and activation of HSL via ERK/PPARγ and PKA signaling pathways, which could lead to developing new strategies for reducing human obesity.
- Type
- article
- Published
- 2011-12-01
- Cited by
- 37
- References
- 41
- Access
- Open access
- OpenAlex
- https://openalex.org/W1994356018
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13380621
Keywords
Perilipin, Lipolysis, Hormone-sensitive lipase, Adipose triglyceride lipase, MAPK/ERK pathway
References
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- Insulin regulates the expression of adiponectin and adiponectin receptors in porcine adipocytes.
- Role of PAT proteins in lipid metabolism.
- Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ
- MAPK- Kinases as Nucleo-Cytoplasmic Shuttles for PPARγ
- Serum amyloid A activates NF‐κB and proinflammatory gene expression in human and murine intestinal epithelial cells
- The Effect of Dietary Docosahexaenoic Acid Enrichment on the Expression of Porcine Hepatic Genes
- The Peroxisome Proliferator-activated Receptor γ Regulates Expression of the Perilipin Gene in Adipocytes*
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- Acute-Phase Serum Amyloid A: An Inflammatory Adipokine and Potential Link between Obesity and Its Metabolic Complications
- ERK1 and ERK2 activate CCAAAT/enhancer-binding protein-beta-dependent gene transcription in response to interferon-gamma.
Cited by
- Dynamic differences in oxidative stress and the regulation of metabolism with age in visceral versus subcutaneous adipose
- The localization and differential expression of Serum Amyloid A in bovine liver and adipose tissue depots.
- Group IIE secretory phospholipase A2 regulates lipolysis in adipocytes
- The Acute Phase Protein Serum Amyloid A Induces Lipolysis and Inflammation in Human Adipocytes through Distinct Pathways
- Dual regulation of adipose triglyceride lipase by pigment epithelium-derived factor: a novel mechanistic insight into progressive obesity.
- Green Tea Polyphenols Reduced Fat Deposits in High Fat-Fed Rats via erk1/2-PPARγ-Adiponectin Pathway
- 10E,12Z-conjugated linoleic acid impairs adipocyte triglyceride storage by enhancing fatty acid oxidation, lipolysis, and mitochondrial reactive oxygen species
- Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways.
- LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity
- Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes[S]
- Palmitic acid follows a different metabolic pathway than oleic acid in human skeletal muscle cells; lower lipolysis rate despite an increased level of adipose triglyceride lipase.
- Study of adipokine secretion and their functions.
- Ice Plant (Mesembryanthemum crystallinum) Extract Promotes Lipolysis in Mouse 3T3-L1 Adipocytes Through Extracellular Signal-Regulated Kinase Activation
- Serum Amyloid a Promotes Visfatin Expression in Macrophages
- Effects of Historical Differences in Components of the Japanese Diet on the Risk of Obesity in Mice
- Isolation and Differentiation of Adipose-Derived Stem Cells from Porcine Subcutaneous Adipose Tissues
- TNF‐α downregulates CIDEC via MEK/ERK pathway in human adipocytes
- Acetylshikonin from Zicao Prevents Obesity in Rats on a High-Fat Diet by Inhibiting Lipid Accumulation and Inducing Lipolysis
- Serum amyloid A links endotoxaemia to weight gain and insulin resistance in mice
- Role of n-3 Polyunsaturated Fatty Acids in Ameliorating the Obesity-Induced Metabolic Syndrome in Animal Models and Humans
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