Predictive Significance of Kidney Myeloid-Related Protein 8 Expression in Patients with Obesity- or Type 2 Diabetes-Associated Kidney Diseases
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Summary
Glomerular MRP8 expression appears to be associated with progression of proteinuria in obese or type 2 diabetic patients, possibly by inducing inflammatory changes in macrophages through TLR4 signaling.
- Type
- article
- Published
- 2014-02-18
- Cited by
- 10
- References
- 31
- Access
- Open access
- OpenAlex
- https://openalex.org/W1970489413
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18587887
Keywords
Medicine, Internal medicine, Diabetic nephropathy, Endocrinology, Proinflammatory cytokine
References
- Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis
- The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells
- Leukocyte and serum S100A8/S100A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis
- Obesity-related glomerulopathy: an emerging epidemic.
- The Expression of Inflammatory Genes Is Upregulated in Peripheral Blood of Patients With Type 1 Diabetes
- Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis
- Renal collecting duct epithelial cells regulate inflammation in tubulointerstitial damage in mice.
- Exacerbation of diabetic nephropathy by hyperlipidaemia is mediated by Toll-like receptor 4 in mice
- MRP-8/14 is Critical for the Biological Response to Vascular Injury
- Evolutionary Medicine: From Dwarf Model Systems to Healthy Centenarians?
- Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice.
- Calprotectin — A Novel Marker of Obesity
- Myeloid-related protein 8 expression on macrophages is a useful prognostic marker for renal dysfunction in children with MPGN type 1.
- Accumulation of macrophages expressing myeloid-related protein 8 associated with the progression of sclerotic changes in children with IgA nephropathy.
- Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
- Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons.
- Clinical and Histological Correlations of Decline in Renal Function in Diabetic Patients With Proteinuria
- Role of the Toll-like Receptor 4/NF-&kgr;B Pathway in Saturated Fatty Acid–Induced Inflammatory Changes in the Interaction Between Adipocytes and Macrophages
- Natriuretic peptide receptor guanylyl cyclase-A protects podocytes from aldosterone-induced glomerular injury.
- Liver angiotensinogen is the primary source of renal angiotensin II.
Cited by
- An Atherogenic Paigen-Diet Aggravates Nephropathy in Type 2 Diabetic OLETF Rats
- A Systems Biology Overview on Human Diabetic Nephropathy: From Genetic Susceptibility to Post-Transcriptional and Post-Translational Modifications
- TLR4 as a possible key regulator of pathological vascular remodeling by Ang II receptor activation
- The Cardiovascular Risk Prognostication in Diabetes Mellitus: The Role of Myeloid-related Protein Complex Calprotectin
- Comprehensive RNA-Sequencing Analysis in Peripheral Blood Cells Reveals Differential Expression Signatures with Biomarker Potential for Idiopathic Membranous Nephropathy
- Ablation of Myeloid Cell MRP8 Ameliorates Nephrotoxic Serum-induced Glomerulonephritis by Affecting Macrophage Characterization through Intraglomerular Crosstalk
- The predictive role of serum calprotectin on mortality in hemodialysis patients with high phosphoremia
- Inhibition of S100A8/A9 ameliorates renal interstitial fibrosis in diabetic nephropathy.
- Expression of Concern: Predictive Significance of Kidney Myeloid-Related Protein 8 Expression in Patients with Obesity- or Type 2 Diabetes-Associated Kidney Diseases
- Additional file 1 of The predictive role of serum calprotectin on mortality in hemodialysis patients with high phosphoremia
- The Myeloid-Related Protein Complex Calprotectin as Biomarker of Cardiovascular Risk in Diabetes Mellitus Patients
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