A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes
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Summary
Two species of nuclear proteins which bind specifically to an octamer sequence, ATTTGCAT, are detected using an electrophoretic mobility shift assay to identify DNA binding proteins.
- Type
- article
- Published
- 1986-10-16
- Cited by
- 540
- References
- 23
- OpenAlex
- https://openalex.org/W1993280477
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4269376
Keywords
Histone octamer, Promoter, Biology, Molecular biology, Electrophoretic mobility shift assay
References
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- An immunoglobulin promoter displays cell-type specificity independently of the enhancer
- Transcription cell type specificity is conferred by an immunoglobulin VH gene promoter that includes a functional consensus sequence.
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- A reliable method for the recovery of DNA fragments from agarose and acrylamide gels.
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- Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements
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- Inducible transcription of the unrearranged kappa constant region locus is a common feature of pre-B cells and does not require DNA or protein synthesis.
- A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes
- During B-cell differentiation enhancer activity and transcription rate of immunoglobulin heavy chain genes are high before mRNA accumulation.
Cited by
- Determination of transcription factor isoelectric point by two-dimensional native isoelectric focusing and electrophoretic mobility shift analysis.
- Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations.
- Description of a polymorphism in the regulatory region of the HLA-DRA gene.
- Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link.
- Inducible nuclear factor binding to the kappa B elements of the human immunodeficiency virus enhancer in T cells can be blocked by cyclosporin A in a signal-dependent manner
- E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor.
- Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer
- Nuclear transcription factor Oct-1 binds to the 5'-upstream region of CYP1A1 and negatively regulates its expression.
- Identification of target genes of the lymphoid-specific transcription factor Oct2.
- Cloning and characterization of the chick Oct binding factor OBF-1.
- Stepwise commitment from embryonic stem to hematopoietic and endothelial cells.
- Homeobox genes in normal hematopoiesis and leukemia.
- Transcriptional regulation of immunoglobulin heavy chain and T-cell receptor beta chain genes.
- POU domain transcription factors in embryonic development
- Rapid identification of novel human lymphoid-restricted genes by automated DNA sequencing of subtracted cDNA libraries.
- The structure and expression of a novel gene activated in early mouse embryogenesis.
- Expression patterns of transcription factors in progressively transformed germinal centers and Hodgkin lymphoma
- Mechanisms of viral-mediated trans-activation of transcription.
- Localization of the inducible enhancer in the mouse interleukin-5 gene that is responsive to T-cell receptor stimulation.
- Experimental models for understanding B lymphocyte formation.
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