Dot1 and Histone H3K79 Methylation in Natural Telomeric and HM Silencing
Explore this paper's citation graph
Summary
The results show that the commonly used URA3 reporter located at TEL-VIIL or at the mating loci may not report on natural PEV and that studies concerning the epigenetic mechanism of silencing in yeast should employ assays that report on the natural pattern of gene expression.
- Type
- article
- Published
- 2011-04-08
- Cited by
- 122
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W1992965842
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1210492
Keywords
URA3, Biology, Gene silencing, DNA methylation, Methylation
References
- Insights into the impact of histone acetylation and methylation on Sir protein recruitment, spreading, and silencing in Saccharomyces cerevisiae.
- Identification and characterization of genes and mutants for an N‐terminal acetyltransferase from yeast.
- Global proteomic analysis of S. cerevisiae (GPS) to identify proteins required for histone modifications.
- The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus
- A suppressor of mating-type locus mutations in Saccharomyces cerevisiae: evidence for and identification of cryptic mating-type loci.
- SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes.
- The Sir4 C-terminal coiled coil is required for telomeric and mating type silencing in Saccharomyces cerevisiae.
- COMPASS, a Histone H3 (Lysine 4) Methyltransferase Required for Telomeric Silencing of Gene Expression*
- A charge-based interaction between histone H4 and Dot1 is required for H3K79 methylation and telomere silencing: identification of a new trans-histone pathway.
- Sir2 deacetylates histone H3 lysine 56 to regulate telomeric heterochromatin structure in yeast.
- Limitations of silencing at native yeast telomeres
- A common telomeric gene silencing assay is affected by nucleotide metabolism
- Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae.
- Transcription and RNA interference in the formation of heterochromatin
- Histone H3 N-terminus regulates higher order structure of yeast heterochromatin
- Dot1p modulates silencing in yeast by methylation of the nucleosome core.
- Interplay of chromatin modifiers on a short basic patch of histone H4 tail defines the boundary of telomeric heterochromatin.
- The Establishment of Gene Silencing at Single-Cell Resolution
- Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription.
- Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell cycle regulation of H3K79 dimethylation
Cited by
- R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants.
- Maintenance of Heterochromatin Boundary and Nucleosome Composition at Promoters by the Asf1 Histone Chaperone and SWR1-C Chromatin Remodeler in Saccharomyces cerevisiae
- Altered histone modifications in cancer.
- The Interaction Between Sir3 and Sir4 is Dispensable for Silent Chromatin Spreading in Budding Yeast
- Lysine Post-Translational Modifications of Saccharomyces Cerevisiae Chromatin Proteins
- Cooperative stabilization of the SIR complex provides robust epigenetic memory in a model of SIR silencing in Saccharomyces cerevisiae
- Cell individuality in adhesin expression of Candida glabrata
- SAGA, TFIID and regulation of transcription through chromatin
- Getting down to the core of histone modifications
- The SUMO E3 Ligase Siz2 Exerts a Locus-Dependent Effect on Gene Silencing in Saccharomyces cerevisiae
- Histone H4 Lysine 20 of Saccharomyces cerevisiae is monomethylated and functions in subtelomeric silencing
- N-alpha-terminal Acetylation of Histone H4 Regulates Arginine Methylation and Ribosomal DNA Silencing
- Transcriptome profiling reveals a novel role for trichostatin A in antagonizing histone chaperone Chz1 mediated telomere anti‐silencing
- Codependency of H2B monoubiquitination and nucleosome reassembly on Chd1.
- Effects of Perinuclear Chromosome Tethers in the Telomeric URA3/5FOA System Reflect Changes to Gene Silencing and not Nucleotide Metabolism
- DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia
- A common telomeric gene silencing assay is affected by nucleotide metabolism
- Cell cycle regulation of silent chromatin formation.
- Sirtuins in Epigenetic Regulation
- The Role of Multiple Marks in Epigenetic Silencing and the Emergence of a Stable Bivalent Chromatin State
Related papers
- Transformation of the yeast Saccharomyces kluyveri by Saccharomyces cerevisiae-based plasmids.
- Construction and application of a gene silencing system using a dual promoter silencing vector in Hypsizygus marmoreus
- Characterization of the Promoter of PRS1 inSaccharomyces cerevisiae Identifies Three Regions Potentially Involved in Control of Expression
- Functional co-operation between the nuclei of Saccharomyces cerevisiae and mitochondria from other yeast species
- Interplay of Developmentally Regulated Gene Expression and Heterochromatic Silencing in Trans in Drosophila
- A novel system of genetic transformation allows multiple integrations of a desired gene in Saccharomyces cerevisiae chromosomes.
- The Mechanisms of Transgene Silencing in Plants and the Decrease