Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

Keywords

Homologous recombination, Replication protein A, Cyclin-dependent kinase 1, Cell biology, Non-homologous end joining

References

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• Cdk1 Targets Srs2 to Complete Synthesis-Dependent Strand Annealing and to Promote Recombinational RepairMarco Saponaro, Devon Callahan, Xiuzhong Zheng — 2010
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• Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break RepairPablo Huertas, Stephen P. Jackson — 2009
• Role of Dnl4–Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombinationYu Zhang, Melissa L. Hefferin, Ling Chen — 2007
• The CDK regulates repair of double‐strand breaks by homologous recombination during the cell cycleYael Aylon, Batia Liefshitz, Martin Kupiec — 2004
• Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand-break resection and resolution of double-Holliday JunctionsKseniya Zakharyevich, Yunmei Ma, Shangming Tang — 2010
• Cell cycle-dependent phosphorylation of Rad53 kinase by Cdc5 and Cdc28 modulates checkpoint adaptationThomas Schleker, Kenji Shimada, Ragna Sack — 2010
• DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1Grzegorz Ira, Achille Pellicioli, Alitukiriza Balijja — 2004
• Saccharomyces CDK1 Phosphorylates Rad53 Kinase in Metaphase, Influencing Cellular Morphogenesis*Laura Diani, Claudia Colombelli, Benjamin Tamilselvan Nachimuthu — 2009
• Break dosage, cell cycle stage and DNA replication influence DNA double strand break responseChristian Zierhut, John F.X. Diffley — 2008
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• Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast.Grzegorz Ira, Anna Malkova, Giordano Liberi — 2003
• Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifsShunichi Kosugi, Masako Hasebe, Masaru Tomita — 2009
• Differential regulation of the cellular response to DNA double-strand breaks in G1.Jacqueline H. Barlow, Michael Lisby, Rodney Rothstein — 2008
• An overview of Cdk1-controlled targets and processesJorrit M. Enserink, Richard D. Kolodner — 2010
• Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III.Thomas Caspari, Johanne M. Murray, Antony M. Carr — 2002

Cited by

• Four pillars of the S-phase checkpoint.Núria Ventura — 2013
• Working hard for recovery: mitotic kinases in the DNA damage checkpointLilian Moncrieff — 2013
• Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA associationJohn James Byrne — 2014
• Biochemical Mechanism of DSB End Resection and its RegulationPeter Lloyd‐Sherlock, Elisabeth Schröder‐Butterfill — 2015
• Sharpening the ends for repair: mechanisms and regulation of DNA resection.Francisco Martínez Ros — 2016
• Immunofluorescence-based methods to monitor DNA end resectionBipasha Mukherjee, Nozomi Tomimatsu, Sandeep Burma — 2015
• Genetic instability is prevented by Mrc1-dependent spatio-temporal separation of replicative and repair activities of homologous recombinationFélix Prado — 2014
• Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisionsNozomi Tomimatsu, Bipasha Mukherjee, Katherine Deland — 2012
• Characterisation of the role of autophagy in DNA damage repairEmma Yu Liu — 2014
• Replication Stress in Mammalian Cells and Its Consequences for MitosisCamille Gelot, Indiana Magdalou, Bernard S. López — 2015
• The cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial design.Ruth Thompson, Alan Eastman — 2013
• Investigation of mechanisms that suppress non-allelic homologous recombinationCarolyn M. George — 2013
• Repair Pathway Choices and Consequences at the Double-Strand BreakRaphaël Ceccaldi, Beatrice Rondinelli, Alan D. D’Andrea — 2015
• Étude du rôle de la phosphorylation du complexe Mre11-Rad50-Xrs2 dans le maintien de l'intégrité génomiqueA. Simoneau — 2013
• DNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homologous Recombination*Petr Ćejka — 2015
• Regulation of recombination and genomic maintenance.Wolf‐Dietrich Heyer — 2015
• Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiaeLorraine S. Symington, Rodney Rothstein, Michael Lisby — 2014
• Nuclease activity of Saccharomyces cerevisiae Dna2 inhibits its potent DNA helicase activityMaryna Levikova, Daniel Klaue, Ralf Seidel — 2013
• Targeting cell cycle regulators in hematologic malignanciesEiman Aleem, R.J. Arceci — 2015
• Okazaki Fragment Processing-independent Role for Human Dna2 Enzyme during DNA Replication*Julien P. Duxin, Hayley R. Moore, Julia M. Sidorova — 2012

Related papers

• Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes.Ling Chen, Kelly M. Trujillo, William Ramos — 2001
• Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complexMuriel Grenon, Chris Gilbert, Noel F. Lowndes — 2001
• Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11Michela Di Virgilio, Jean Gautier — 2005
• The Mre11/Rad50/Xrs2 complex and non-homologous end-joining of incompatible ends in S. cerevisiae.Xiaoming Zhang, Tanya T. Paull — 2005
• Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombinationSandra Muñoz-Galván, Ana López-Saavedra, Stephen P. Jackson — 2012
• Detection and repair of ionizing radiation induced DNA double strand breaks: new developments in non-homologous end joiningChen Wang, Susan P. Lees‐Miller — 2013
• The non-homologous end-joining protein Nej1p is a target of the DNA damage checkpointPeter Ahnesorg, Stephen P. Jackson — 2006
• Mre11: roles in DNA repair beyond homologous recombinationShan Zha, Cristian Boboilă, Frederick W. Alt — 2009
• Homologous Recombination-Mediated DNA Repair and Implications for Clinical Treatment of Repair Defective Cancers.Nicole M. Reilly, Brian D. Yard, Douglas L. Pittman — 2019