A pilot study of allogeneic cellular therapy for patients with advanced hematologic malignancies.
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Summary
Results from this patient suggest that allogeneic therapy induced a host anti-tumor response associated with cytotoxic T cells reactive with a low affinity self-antigen, similar to that induced by graft-versus-host (GVHD) prophylaxis.
- Type
- article
- Published
- 2008-12-01
- Cited by
- 14
- References
- 52
- OpenAlex
- https://openalex.org/W1990192408
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13155668
Keywords
Hematologic Neoplasms, Medicine, Hematologic malignancy, Hematologic disease, Hematologic disorders
References
- Innate immune recognition and suppression of tumors.
- Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia
- Progress in human tumour immunology and immunotherapy
- Graft-versus-tumor induction with donor leukocyte infusions as primary therapy for patients with malignancies.
- Tumor microenvironments, the immune system and cancer survival
- Antitumor effect of donor marrow graft rejection induced by recipient leukocyte infusions in mixed chimeras prepared with nonmyeloablative conditioning: critical role for recipient-derived IFN-gamma.
- High PR3 or ELA2 expression by CD34+ cells in advanced-phase chronic myeloid leukemia is associated with improved outcome following allogeneic stem cell transplantation and may improve PR1 peptide-driven graft-versus-leukemia effects.
- Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies.
- The graft versus leukemia response after allogeneic hematopoietic stem cell transplantation.
- Expansion of CD8+ Cytotoxic T Cells in vitro and in vivo Using MHC Class I Tetramers
- Cancer regression in patients with metastatic melanoma after the transfer of autologous antitumor lymphocytes
- Current status of haploidentical stem cell transplantation
- A novel flow cytometric assay for quantitation and multiparametric characterization of cell-mediated cytotoxicity.
- Tumor-specific human CD4+ regulatory T cells and their ligands: implications for immunotherapy.
- Cellular immune therapy for refractory cancers: novel therapeutic strategies.
- Graft-versus-Host Disease, the Graft-versus-Leukemia Effect, and Mixed Chimerism following Nonmyeloablative Stem Cell Transplantation
- Donor Lymphocyte Infusion: The Use of Alloreactive and Tumor-Reactive Lymphocytes for Immunotherapy of Malignant and Nonmalignant Diseases in Conjunction with Allogeneic Stem Cell Transplantation
- Nonmyeloablative blood stem cell transplantation as adoptive allogeneic immunotherapy for metastatic renal cell carcinoma.
- Minor histocompatibility antigens: allo target molecules for tumor-specific immunotherapy.
- The immunobiology of cancer immunosurveillance and immunoediting.
Cited by
- Immunotherapy prospects for acute myeloid leukaemia
- Irradiated allogeneic cells enhance umbilical cord blood stem cell engraftment in immunodeficient mice
- Infusion of HLA-mismatched peripheral blood stem cells improves the outcome of chemotherapy for acute myeloid leukemia in elderly patients.
- Harnessing the power of alloreactivity without triggering graft-versus-host disease: how non-engrafting alloreactive cellular therapy might change the landscape of acute myeloid leukemia treatment.
- HLA-mismatched stem-cell microtransplantation as postremission therapy for acute myeloid leukemia: long-term follow-up.
- Transplantation tolerance: from theory to clinic
- Clinical Studies in Hematologic Microtransplantation
- Recipient and donor cells in the graft-versus-solid tumor effect: It takes two to tango.
- Induction of anti-leukemic responses by stimulation of leukemic CD3+ cells with allogeneic stimulator cells
- HLA-mismatched stem cell microtransplantation compared to matched-sibling donor transplantation for intermediate/high-risk acute myeloid leukemia
- Current state of nonengrafting donor leukocyte infusion (focus on microtransplantation for acute myeloid leukemia).
- Comparison of microtransplantation, chemotherapy and allogeneic transplantation in post-remission therapy for Philadelphia chromosome-positive acute lymphoblastic leukemia.
- Trial Watch: Adoptive TCR-Engineered T-Cell Immunotherapy for Acute Myeloid Leukemia
- CD137-selektierte leukämiereaktive T-Zellen gesunder Spender zur adoptiven Immuntherapie stammzelltransplantierter Leukämiepatienten
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