Long-term regulated expression of growth hormone in mice after intramuscular gene transfer.
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Summary
In vivo regulation of gene expression after intramuscular injection of two separate adenovirus or adeno-associated virus (AAV) vectors, one encoding an inducible human growth hormone (hGH) target gene and the other a bipartite rapamycin-regulated transcription factor are demonstrated.
- Type
- article
- Published
- 1999-07-20
- Cited by
- 182
- References
- 34
- Access
- Open access
- OpenAlex
- https://openalex.org/W1989429684
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27634585
Keywords
Genetic enhancement, Transgene, Gene expression, Biology, In vivo
References
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- Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis
- Transduction of Dendritic Cells by DNA Viral Vectors Directs the Immune Response to Transgene Products in Muscle Fibers
- Human growth hormone as a reporter gene in regulation studies employing transient gene expression
- Immune responses to transgene–encoded proteins limit the stability of gene expression after injection of replication–defective adenovirus vectors
- A humanized system for pharmacologic control of gene expression
- Molecular cloning and overexpression of the human FK506-binding protein FKBP
- Regulated delivery of therapeutic proteins after in vivo somatic cell gene transfer.
- Efficient and Stable Adeno-Associated Virus-Mediated Transduction in the Skeletal Muscle of Adult Immunocompetent Mice
- Controlling gene expression using synthetic ligands.
- Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus.
- Pharmacologic control of a humanized gene therapy system implanted into nude mice.
- Gene therapy: adenovirus vectors.
- Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.
- Recombinant adeno-associated virus for muscle directed gene therapy
- Direct intramuscular injection with recombinant AAV vectors results in sustained expression in a dog model of hemophilia
- Adenovirus-mediated regulable target gene expression in vivo.
- Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic protein.
Cited by
- Efficient Gene Delivery Using Anionic Liposome-Complexed Polyplexes (LPDII)
- Ligand-regulatable erythropoietin production by plasmid injection and in vivo electroporation.
- Adeno-Associated Virus 2-Mediated Antiangiogenic Cancer Gene Therapy
- Dimerizer regulation of AADC expression and behavioral response in AAV-transduced 6-OHDA lesioned rats.
- Enhancing the Utility of Adeno-Associated Virus Gene Transfer through Inducible Tissue-Specific Expression
- Converging Technologies for Improving Human Performance
- Regulatable and cell-type specific transgene expression in glial cells: prospects for gene therapy for neurological disorders.
- Overview of adeno-associated viral vectors.
- Viral vectors: a wide range of choices and high levels of service.
- Développement de vecteurs lentiviraux régulables pour le transfert de gène dans le système nerveux central
- Engineered Hair Follicle Mesenchymal Stem Cells Overexpressing Controlled-Release Insulin Reverse Hyperglycemia in Mice with Type l Diabetes
- Optimizing regulatable gene expression using adenoviral vectors
- Ecdysteroid receptors and their applications in agriculture and medicine.
- Intravenous AAV8 Encoding Urocortin-2 Increases Function of the Failing Heart in Mice
- Allosteric activation of kinases: Design and application of RapR kinases
- Transfert de gène in vivo: étude, régulation et application de l'électrotransfert
- Air-conditioning for regulated transgene expression
- An antibody delivery system for regulated expression of therapeutic levels of monoclonal antibodies in vivo.
- Antiangiogenic cancer gene therapy by adeno-associated virus 2-mediated stable expression of the soluble FMS-like tyrosine kinase-1 receptor
- Dimerizer-regulated gene expression.
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