Ubiquitination of Histone H2B by Rad6 Is Required for Efficient Dot1-mediated Methylation of Histone H3 Lysine 79*
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Summary
It is shown that Rad6-mediated ubiquitination of H2B lysine 123 is important for efficient methylation of lysin 79, but not lysines 36, of histone H3, and this study suggests that Rad 6 affects telomeric silencing, at least in part, by influencingmethylation of hist one H3.
- Type
- article
- Published
- 2002-09-20
- Cited by
- 479
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W1989092936
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13407601
Keywords
Histone H3, Histone methyltransferase, Histone methylation, Histone code, Histone H2A
References
- Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast
- The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4
- Additional modules for versatile and economical PCR‐based gene deletion and modification in Saccharomyces cerevisiae
- COMPASS, a Histone H3 (Lysine 4) Methyltransferase Required for Telomeric Silencing of Gene Expression*
- Rad6-dependent ubiquitination of histone H2B in yeast.
- Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain.
- The many faces of histone lysine methylation.
- Gene silencing: Trans-histone regulatory pathway in chromatin
- Set2 Is a Nucleosomal Histone H3-Selective Methyltransferase That Mediates Transcriptional Repression
- Dot1p modulates silencing in yeast by methylation of the nucleosome core.
- Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase.
- Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanism.
- A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3
- Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress.
- Disruptor of Telomeric Silencing-1 Is a Chromatin-specific Histone H3 Methyltransferase*
- A conserved sequence in histone H2A which is a ubiquitination site in higher eucaryotes is not required for growth in Saccharomyces cerevisiae
- PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin.
- Methylation of Histone H3 by COMPASS Requires Ubiquitination of Histone H2B by Rad6*
- Dynamics of global histone acetylation and deacetylation in vivo: rapid restoration of normal histone acetylation status upon removal of activators and repressors.
- Crystal structure of the nucleosome core particle at 2.8 Å resolution
Cited by
- Asf1 mediates histone eviction and deposition during elongation by RNA polymerase II.
- Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states
- DSIF and RNA Polymerase II CTD Phosphorylation Coordinate the Recruitment of Rpd3S to Actively Transcribed Genes
- The Saccharomyces cerevisiae Paf1 transcription elongation complex is connected to chromatin modification through the multifunctional Rtf1 subunit and the inositol polyphosphate signaling pathway
- Dynamic histone modifications at the promoters of Hox genes in embryonic stem cells
- Significance of Protein Interactions in Mediating AF9 Function
- IDENTIFICATION AND CHARACTERIZATION OF FACTORS REQUIRED FOR REPRESSION OF THE YEAST SER3 GENE BY SRG1 INTERGENIC TRANSCRIPTION
- Chromatin Remodeling and Transcriptional Memory: A Dissertation
- Analysis of chromatin modification and remodeling in the transcriptional regulation of the Wnt/Wg pathway
- EPIGENETICS-EPIDISEASES-EPIDRUGS
- Histone ubiquitylation and the regulation of transcription.
- Chromatin dynamics and Arabidopsis development
- Role of HSWI/SNF associated PRMT5 and MSIN3A/HDAC in the control of gene expression and cancer.
- The role of Dot1l in normal hematopoiesis and MLL translocation leukemia
- Introduction—Epiphanies in Epigenetics
- Mechanisms of transcription elongation on chromatin and gene silecing
- Role of Histone Metabolism and Chromatin Structure in DNA Repair
- The roles of the Saccharomyces cerevisiae Paf1 complex in regulating transcriptional repression
- A role for Sum1 in HML silencing and replication initiation in Saccharomyces cerevisiae
- Examining the contribution of chromatin and chromatin associated factors to transcription regulation
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