Recognition of Hyaluronan Released in Sterile Injury Involves a Unique Receptor Complex Dependent on Toll-like Receptor 4, CD44, and MD-2*
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Summary
A previously unknown mechanism for initiation of sterile inflammation that involves recognition of released hyaluronan fragments as an endogenous signal of tissue injury is defined.
- Type
- article
- Published
- 2007-06-22
- Cited by
- 391
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W1988760595
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37897674
Keywords
Toll, Receptor, Toll-like receptor, Cell biology, Chemistry
References
- Genetic analysis of innate immunity: identification and function of the TIR adapter proteins.
- The p38 Mitogen-activated Kinase Pathway Regulates the Human Interleukin-10 Promoter via the Activation of Sp1 Transcription Factor in Lipopolysaccharide-stimulated Human Macrophages*
- Hyaluronic acid-induced lymphocyte signal transduction and HA receptor (GP85/CD44)-cytoskeleton interaction.
- Resolution of Lung Inflammation by CD44
- Endotoxin recognition and signal transduction by the TLR4/MD2-complex.
- Hyaluronan Oligosaccharides Induce Matrix Metalloproteinase 13 via Transcriptional Activation of NFκB and p38 MAP Kinase in Articular Chondrocytes*
- Hyaluronan Fragments Induce Nitric-oxide Synthase in Murine Macrophages through a Nuclear Factor κB-dependent Mechanism*
- Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation.
- TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway
- Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice.
- Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4
- Group A Streptococcus tissue invasion by CD44-mediated cell signalling
- Lipopolysaccharide Rapidly Traffics to and from the Golgi Apparatus with the Toll-like Receptor 4-MD-2-CD14 Complex in a Process That Is Distinct from the Initiation of Signal Transduction* 210
- Unresponsiveness of MyD88-deficient mice to endotoxin.
- Dermatan Sulfate Released after Injury Is a Potent Promoter of Fibroblast Growth Factor-2 Function*
- Hyaluronan Fragments Stimulate Endothelial Recognition of Injury through TLR4*
- CD14 is required for MyD88-independent LPS signaling
- ERM proteins: head-to-tail regulation of actin-plasma membrane interaction.
- Inferences, questions and possibilities in Toll-like receptor signalling
- Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
Cited by
- Early events in the recognition of danger signals after tissue injury
- Hyaluronan fragments contribute to the ozone-primed immune response to LPS
- The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matter.
- Toll-Like Receptor 4 Activation in Cancer Progression and Therapy
- The inhibition of hyaluronan degradation reduced pro‐inflammatory cytokines in mouse synovial fibroblasts subjected to collagen‐induced arthritis
- Skin Microbiome and Skin Disease: The Example of Rosacea
- Hyaluronan ameliorates LPS-induced acute lung injury in mice via Toll-like receptor (TLR) 4-dependent signaling pathways.
- RAGE and TLRs as Key Targets for Antiatherosclerotic Therapy
- The Role of Hyaluronan Treatment in Intestinal Innate Host Defense
- Modulatory activities of glycosaminoglycans and other polyanionic polysaccharides on cationic antimicrobial peptides
- Immunogénicite de la mort cellulaire induite par les chimiothérapies anti-cancéreuses
- Toll-like Rezeptor 3 und Toll-like Rezeptor 4 im gesunden und pathologisch veränderten humanen Endometrium
- Importance of Hyaluronan Metabolism and Signalling in Tumour Progression
- Lactoferrin and its Role in Wound Healing
- Etude de l'effet antitumoral de l'activation de la NO-synthase inductible dans un modèle de cancer du sein : analyse des mécanismes moléculaires
- Understanding how injured tissue communicates with the immune system
- Udział receptorów TLR rozpoznających wzorce molekularne organizmów patogennych w modulowaniu aktywności regulatorowych limfocytów T CD4+CD25+FoxP3+
- High and low molecular weight hyaluronic acid differentially influence macrophage activation
- Chondrocyte Innate Immune MyD88-dependent Signaling Drives Pro-Catabolic Effects of the Endogenous TLR2/TLR4 Ligands LMW-HA and HMGB1
- Immunomodulation by Shark Cartilage Extracts
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