Toll-Like Receptor 4 Activation in Cancer Progression and Therapy
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Summary
Research of the role and mechanisms of TLR4 activation in cancer may provide novel antitumor vaccine adjuvants as well asTLR4 inhibitors that could prevent inflammation-induced carcinogenesis.
- Type
- article
- Published
- 2011-11-03
- Cited by
- 161
- References
- 136
- Access
- Open access
- OpenAlex
- https://openalex.org/W22110526
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1512638
Keywords
Tribunal, Political science, Humanities, Art, Law
References
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- Biological effect of OK-432 (picibanil) and possible application to dendritic cell therapy.
- Toll-like Receptor 4 Activation Increases Akt Phosphorylation in Colon Cancer Cells
- TLR4‐mediated skin carcinogenesis is dependent on immune and radioresistant cells
- The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein.
- High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer
- The hallmarks of cancer
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- Enhancement of antitumor effect using dendritic cells activated with natural killer cells in the presence of Toll-like receptor agonist
- The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages.
Cited by
- siRNA and cancer immunotherapy.
- Perioperative treatment with the new synthetic TLR-4 agonist GLA-SE reduces cancer metastasis without adverse effects
- TLR4 siRNA inhibits proliferation and invasion in colorectal cancer cells by downregulating ACAT1 expression.
- Immunopharmacology of Lipid A Mimetics
- TLR4-MyD88-TRAF6-TAK1 Complex-Mediated NF-κB Activation Contribute to the Anti-Inflammatory Effect of V8 in LPS-Induced Human Cervical Cancer SiHa Cells
- TLR4 activation by lipopolysaccharide confers survival advantage to growth factor deprived prostate cancer cells
- HIF-1 at the crossroads of hypoxia, inflammation, and cancer
- Toll-like receptor 5 (TLR5) expression is a novel predictive marker for recurrence and survival in squamous cell carcinoma of the tongue
- Positive link between variant Toll-like receptor 4 (Asp299Gly and Thr399Ile) and colorectal cancer patients with advanced stage and lymph node metastasis
- Biological role of Toll-like receptor-4 in the brain.
- Drying enhances immunoactivity of spent brewer's yeast cell wall β-D-glucans.
- Trial Watch
- Epigenetic Regulation of Toll-Like Receptor Signaling: Implications for Cancer Development
- Should a Toll-like receptor 4 (TLR-4) agonist or antagonist be designed to treat cancer? TLR-4: its expression and effects in the ten most common cancers
- Association between Toll-like receptor 3 polymorphisms and cancer risk: a meta-analysis
- TLR4-dependant immune response, but not hepatitis B virus reactivation, is important in radiation-induced liver disease of liver cancer radiotherapy
- A magnetic switch for the control of cell death signalling in in vitro and in vivo systems.
- HMGB1 in Hormone-Related Cancer: a Potential Therapeutic Target
- Trial watch
- Toll-like receptor 9 mediates invasion and predicts prognosis in squamous cell carcinoma of the mobile tongue.
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