Role of LAG-3 in regulatory T cells.

Summary

It is proposed that LAG-3 marks regulatory T cell populations and contributes to their suppressor activity, which reduces their proliferative capacity and confers on them suppressionor activity toward effector T cells.

Keywords

Effector, Biology, IL-2 receptor, Cell biology, Immunology

References

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Regulatory T-cells, FoxP3 and atherosclerosis.Michal Entin‐Meer, Arnon Afek, Jacob George — 2009
Therapeutic immunomodulation of allergic lung disease using regulatory dendritic cells in a mouse model of asthmaAarti Nayyar — 2009
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T regulatory cells: aid or hindrance in the clearance of disease?Esteban Alemán Ruiz — 2007
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Expression of LAG-3 is coincident with the impaired effector function of HBV-specific CD8(+) T cell in HCC patients.Maria Ignez Ramos da Silva Regenin — 2013
An IL-27/Lag3 axis enhances Foxp3+ regulatory T cell suppressive function and therapeutic efficacyMalcolm D. Evans — 2015
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The influence of biologic therapy on the capacity of regulatory T cells to restrain Th17 responsesJenny L. McGovern — 2012
Role and specificity of regulatory T cells during retroviral infectionInês Antunes — 2009
Insights into transcriptional regulation by FOXP3.Bryan, D. Carson — 2006
Influence des lymphocytes T CD4+ CD25+ régulateurs sur la dynamique de formation de la synapse immunologique entre un lymphocyte T CD4+ effecteur et une cellule présentatrice d'antigèneMichaël Esquerré — 2007
Untersuchungen zur B-Zell-Rekonstitution nach allogener StammzelltransplantationKristina Doser — 2012
T regulatory cells and the germinal centerCarla‐Maria Alexander — 2011
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Immunregulatorische Funktion humaner TCRab+ CD4- CD8- T-LymphozytenSimon Völkl — 2008

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