Role of tumor suppressor p53 domains in selective binding to supercoiled DNA.

Explore this paper's citation graph

Summary

It is demonstrated here that the p53 C-terminal domain (amino acids 347-382) and a p53 oligomeric state are important for SCS binding and a model according to which two DNA duplexes are compacted into p53-scDNA filaments is proposed and a role for filament formation in recombination is discussed.

Type
article
Published
2002-11-15
Cited by
54
References
59
Access
Open access

Keywords

Biology, Mutant, DNA, Molecular biology, HMG-box

References

Cited by

Related papers