17β-Estradiol attenuates hypoxic pulmonary hypertension via estrogen receptor-mediated effects.
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Summary
E2 attenuates hemodynamic and remodeling parameters in HPH in an ER-dependent manner, through direct antiproliferative mechanisms on vascular cells, which may provide novel nonhormonal therapeutic targets for HPH.
- Type
- article
- Published
- 2012-05-01
- Cited by
- 159
- References
- 83
- Access
- Open access
- OpenAlex
- https://openalex.org/W1987540231
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44822254
Keywords
Medicine, Pulmonary hypertension, Estrogen, Estrogen receptor, Hypoxia (environmental)
References
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- Estrogen receptor beta mediates increased activation of PI3K/Akt signaling and improved myocardial function in female hearts following acute ischemia.
- Right Ventricular Function in Cardiovascular Disease, Part II: Pathophysiology, Clinical Importance, and Management of Right Ventricular Failure
- Acute haemodynamic effects of cromakalim in patients with angina pectoris.
- Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women.
- Pulmonary hypertension in women
- Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension.
- Molecular and Cellular Basis of Cardiovascular Gender Differences
- Female sex and estrogen receptor-beta attenuate cardiac remodeling and apoptosis in pressure overload.
Cited by
- Melatonin attenuates hypoxic pulmonary hypertension by inhibiting the inflammation and the proliferation of pulmonary arterial smooth muscle cells
- Autophagy in Vascular Disease
- Neonatal Iron Deficiency Causes Abnormal Phosphate Metabolism by Elevating FGF23 in Normal and ADHR Mice
- The influence of gender and sex hormones in the development of translational and experimental pulmonary arterial hypertension
- Estrogen metabolism in pulmonary arterial hypertension
- Pulmonary arterial hypertension: basis of sex differences in incidence and treatment response
- Major cardiac surgery induces an increase in sex steroids in prepubertal children.
- Interaction between Bone Morphogenetic Protein Receptor Type 2 and Estrogenic Compounds in Pulmonary Arterial Hypertension
- Direct and indirect protection of right ventricular function by estrogen in an experimental model of pulmonary arterial hypertension.
- Molecular pathogenesis of pulmonary arterial hypertension.
- Endogenous Estrogen Attenuates Hypoxia-Induced Pulmonary Hypertension by Inhibiting Pulmonary Arterial Vasoconstriction and Pulmonary Arterial Smooth Muscle Cells Proliferation
- Intersectin-1s: An Important Regulator of Cellular and Molecular Pathways in Lung Injury
- Selective Endothelin-A Receptor Blockade Attenuates Endotoxin-Induced Pulmonary Hypertension and Pulmonary vascular dysfunction
- Estradiol improves right ventricular function in rats with severe angioproliferative pulmonary hypertension: effects of endogenous and exogenous sex hormones.
- Sex differences in response to pulmonary arterial hypertension therapy: is what's good for the goose, good for the gander?
- In vivo knockdown of intersectin-1s alters endothelial cell phenotype and causes microvascular remodeling in the mouse lungs
- The effects of gender difference on monocrotaline-induced pulmonary hypertension in rats
- Hypoxic Pulmonary Vasoconstriction
- Oestrogen receptor alpha in pulmonary hypertension
- Novel assessment of haemodynamic kinetics with acute exercise in a rat model of pulmonary arterial hypertension
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