Cytogenetic damage and the radiation-induced G1-phase checkpoint.
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Summary
The results suggest that the presence of a well-defined p53-dependent G1-phase arrest does not reduce chromosomal aberrations caused by low doses of ionizing radiation markedly, but may reduce the overall degree of survival by triggering other G 1-phase events.
- Type
- article
- Published
- 1996-03-01
- Cited by
- 47
- References
- 32
- OpenAlex
- https://openalex.org/W1986731609
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36363379
Keywords
G2-M DNA damage checkpoint, Mitosis, DNA damage, Biology, Cell cycle checkpoint
References
- Chromosome aberrations and radiation-induced cell death. I. Transmission and survival parameters of aberrations.
- Suppression of acute lymphoblastic leukemia by the human wild-type p53 gene.
- Participation of p53 protein in the cellular response to DNA damage.
- Cell checkpoint and radiosensitivity
- The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae.
- A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.
- Variations in several responses of HeLa cells to x-irradiation during the division cycle.
- Delayed Initiation of DNA Synthesis in Irradiated Human Diploid Cells
- Statistical Method in Biological Assay
- Transformation and radiosensitivity of human diploid skin fibroblasts transfected with SV40 T-antigen mutants defective in RB and P53 binding domains.
- p53: a frequent target for genetic abnormalities in lung cancer.
- Comparative human cellular radiosensitivity: I. The effect of SV40 transformation and immortalisation on the gamma-irradiation survival of skin derived fibroblasts from normal individuals and from ataxia-telangiectasia patients and heterozygotes.
- DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
- Radiation-induced cellular reproductive death and chromosome aberrations.
- A death in the life of p53
- Mutations in the p53 gene occur in diverse human tumour types
- p53 mutations increase resistance to ionizing radiation.
- Effect of confluent holding on potentially lethal damage repair, cell cycle progression, and chromosomal aberrations in human normal and ataxia-telangiectasia fibroblasts.
- Observations of radiation-induced chromosome fragment loss in live mammalian cells in culture, and its effect on colony-forming ability.
- Chromosome aberrations and radiation-induced cell death. II. Predicted and observed cell survival.
Cited by
- The role of radiation-induced apoptosis as a determinant of tumor responses to radiation therapy
- Induction of apoptosis in bone marrow cells after treatment of mice with WR-2721 and gamma-rays: Relationship to the cell cycle
- Wirkung ionisierender Strahlung auf verschiedene Lungengewebe epithelialen Ursprungs
- Radiosensitivity of thymidylate synthase-deficient human tumor cells is affected by progression through the G1 restriction point into S-phase: implications for fluoropyrimidine radiosensitization.
- Explaining differences in sensitivity to killing by ionizing radiation between human lymphoid cell lines.
- The p53 gene as a modifier of intrinsic radiosensitivity: implications for radiotherapy.
- Dilution of Irradiated Cell Conditioned Medium and the Bystander Effect
- Role of cell cycle control in radiosensitization of mouse spermatogonial stem cells
- Effects of radiation on cerebral vasculature: a review.
- Endothelial cells co‐cultured with wild‐type and dominant/negative p53‐transfected glioblastoma cells exhibit differential sensitivity to radiation‐induced apoptosis
- Mechanisms of the origin of chromosomal aberrations.
- Characterization of p53 in Chinese hamster cell lines CHO-K1, CHO-WBL, and CHL: implications for genotoxicity testing.
- Effects of X-rays and cigarette smoking on leukocyte, lymphocyte and mitotic index values and SCE rates: the relationship between mitotic index and lymphocyte count
- Development of a hypoxia-inducible cytosine deaminase expression vector for gene-directed prodrug cancer therapy
- γ‐Irradiation‐induced cell cycle arrest and cell death in a human submandibular gland cell line: Effect of E2F1 expression
- G2/M is a critical phase to regulate X-ray-induced apoptosis in EL-4 mouse lymphoma cells
- Overexpression of bax in human glioma cell lines.
- Primary mouse fibroblasts deficient for c-Fos, p53 or for both proteins are hypersensitive to UV light and alkylating agent-induced chromosomal breakage and apoptosis.
- Computational Modeling of Signaling Pathways Mediating Cell Cycle Checkpoint Control and Apoptotic Responses to Ionizing Radiation-Induced DNA Damage
- Advances in cell separation: recent developments in counterflow centrifugal elutriation and continuous flow cell separation.
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