Coagulation system and platelets are fully activated in uncomplicated sepsis
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Summary
In severe sepsis and mainly in septic shock, coagulation factors were markedly decreased, global coagulations tests were prolonged, and PTL was reduced, all changes were independent of the causative infectious pathogen.
- Type
- article
- Published
- 2000-02-01
- Cited by
- 283
- References
- 38
- OpenAlex
- https://openalex.org/W1984881453
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2311654
Keywords
Medicine, Partial thromboplastin time, Sepsis, Septic shock, Prothrombin time
References
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- Coagulant activity of leukocytes. Tissue factor activity.
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- Protection of factor Xa from neutralization by the heparin-antithrombin complex.
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- The role of low molecular weight dextran on platelet pulmonary trapping during endotoxin-induced shock.
- Septic shock in humans. Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy.
- Cultured human endothelial cells generate tissue factor in response to endotoxin.
- Guidelines for the Use of Innovative Therapies in Sepsis
- Activation and inhibition of Hageman factor-dependent pathways and the complement system in uncomplicated bacteremia or bacterial shock.
- A prospective study of platelets and plasma proteolytic systems during the early stages of Rocky Mountain spotted fever.
Cited by
- A rational approach to the diagnosis and management of thrombocytopenia in the hospitalized patient.
- Platelet proteomics applied to the search for novel antiplatelet therapeutic targets
- Charakterystyka kliniczna i laboratoryjna dzieci z sepsą
- Mechanism of Ascorbate Protection Against Sepsis-Induced Capillary Blood Flow Impairment
- The effects of antithrombin-III on inducible nitric oxide synthesis in experimental obstructive jaundice. An immunohistochemical study.
- Is the fall in platelet count associated with intensive care unit acquired pneumonia?
- Antimicrobial peptides versus invasive infections.
- Fibrinolytic and procoagulant activity in septic and haemorrhagic shock
- Rolle der von Willebrand-Faktor-spaltenden-Protease ADAMTS-13 bei Patienten mit systemischer Inflammation
- Host-Pathogen Interactions in Streptococcal Diseases
- Effects of terlipressin on patients with sepsis via improving tissue blood flow.
- Rac1 signaling regulates platelet-dependent inflammation abdominal sepsis
- Sepsis: un reto para el internista
- Auswirkung von niedrig dosiertem Hydrokortison auf die Gerinnungsparameter bei Patienten im septischen Schock
- Cardiovascular markers and mediators in human septic shock
- Role of angiostatin in neutrophil biology and acute lung injury
- Platelets: a critical link between inflammation and microvascular dysfunction
- Coagulation abnormalities in critically ill patients
- A randomized clinical trial of unfractioned heparin for treatment of sepsis (the HETRASE study): design and rationale [NCT00100308]
- Platelet aggregation and blood rheology in severe sepsis/septic shock: relation to the Sepsis‐related Organ Failure Assessment (SOFA) score
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