The CGL1 (HeLa × Normal Skin Fibroblast) Human Hybrid Cell Line: A History of Ionizing Radiation Induced Effects on Neoplastic Transformation and Novel Future Directions in SNOLAB
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Summary
The history of the CGL1 neoplastic transformation model system from its initial development through the wide variety of studies examining the effects of all types of ionizing radiation on neoplastically transformed cells cell surface is reviewed.
- Type
- review
- Published
- 2017-09-05
- Cited by
- 15
- References
- 132
- OpenAlex
- https://openalex.org/W2752307697
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9815901
Keywords
Neoplastic transformation, HeLa, Neoplastic cell, Carcinogen, Carcinogenesis
References
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- The Sudbury Neutrino Observatory
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- Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles.
- Human chromosomes which affect tumorigenicity in hybrids of diploid human with heteroploid human or rodent cells.
Cited by
- The REPAIR Project: Examining the Biological Impacts of Sub-Background Radiation Exposure within SNOLAB, a Deep Underground Laboratory
- Fruit Flies Provide New Insights in Low-Radiation Background Biology at the INFN Underground Gran Sasso National Laboratory (LNGS)
- The Cytotoxic Effect of Metformin on Cervical Cancer (Hela) Cells in Comparison with Non-Cancerous Kidney Cells
- Transcriptomic profiling of gamma ray induced mutants from the CGL1 human hybrid cell system reveals novel insights into the mechanisms of radiation-induced carcinogenesis.
- A Research Environment 2 km Deep-Underground Impacts Embryonic Development in Lake Whitefish (Coregonus clupeaformis)
- A novel specialized tissue culture incubator designed and engineered for radiobiology experiments in a sub-natural background radiation research environment.
- Evaluation of Histone Deacetylase Inhibitors as Radiosensitizers for Proton and Light Ion Radiotherapy
- Dose-Rate Effects of Protons and Light Ions for DNA Damage Induction, Survival and Transformation in Apparently Normal Primary Human Fibroblasts
- Identification of Radiation-Induced miRNA Biomarkers Using the CGL1 Cell Model System
- The REPAIR Project, a Deep-Underground Radiobiology Experiment Investigating the Biological Effects of Natural Background Radiation: The First 6 Years
- Genomic Loss and Epigenetic Silencing of the FOSL1 Tumor Suppressor Gene in Radiation-induced Neoplastic Transformation of Human CGL1 Cells Alters the Tumorigenic Phenotype In Vitro and In Vivo
- Overexpression of FRA1 (FOSL1) Leads to Global Transcriptional Perturbations, Reduced Cellular Adhesion and Altered Cell Cycle Progression
- The Role of Natural Background Radiation in Maintaining Genomic Stability in the CGL1 Human Hybrid Model System
- Antioxidants Acteoside and Orientin as Emerging Agents in Synergistic Cancer Therapy: A Focus on Innovative Applications
- FRA1 (FOSL1) suppresses neoplastic transformation and modulates radiation responses via transcriptional control of mitogenic and stress-responsive networks
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