Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes.
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Summary
The presented data support the idea that adiponectin might be of critical relevance for cytokine regulation in obesity and fatty liver diseases affecting primarily macrophage functions and could represent a fundamental link between over-nutrition and an impaired inflammatory immune response.
- Type
- article
- Published
- 2004-10-15
- Cited by
- 852
- References
- 12
- OpenAlex
- https://openalex.org/W1984595457
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28002741
Keywords
Adiponectin, Cytokine, Adipose tissue, Immune system, Adipocyte
References
- Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages.
- Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10.
- Biological properties of interleukin 10.
- Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine.
- Adiponectin differentially regulates cytokines in porcine macrophages.
- Polymorphonuclear (PMN) Function after Small Intestinal Shunt Operation for Morbid Obesity
- Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
- Preadipocyte Conversion to Macrophage
- Interleukin‐10 differentially regulates B7‐1 (CD80) and B7‐2 (CD86) expression on human peripheral blood dendritic cells
- IMMUNOCOMPETENCE IN OBESITY
- Adipose tissue as an endocrine organ.
- Interleukin-10: An Inhibitor of Macrophage-Dependent Stimulation of Th1 Cells
Cited by
- Chondrogenic Differentiation Alters the Immunosuppressive Property of Bone Marrow‐Derived Mesenchymal Stem Cells, and the Effect Is Partially due to the Upregulated Expression of B7 Molecules
- Serum adiponectin is positively associated with lung function in young adults, independent of obesity: The CARDIA study
- Calorie Restriction with a High-Fat Diet Effectively Attenuated Inflammatory Response and Oxidative Stress-Related Markers in Obese Tissues of the High Diet Fed Rats
- Clear association between serum levels of adipokines and T‐helper 17‐related cytokines in patients with psoriasis
- Obesity, adipokines and neuroinflammation.
- Fish Oil-Derived Long-Chain n-3 Polyunsaturated Fatty Acids Reduce Expression of M1-Associated Macrophage Markers in an ex vivo Adipose Tissue Culture Model, in Part through Adiponectin
- Metabolic control of immune tolerance in health and autoimmunity.
- Exercise Training Attenuates the Dysregulated Expression of Adipokines and Oxidative Stress in White Adipose Tissue
- Adipokines in inflammatory lung diseases
- Decreasing CB1 receptor signaling in Kupffer cells improves insulin sensitivity in obese mice
- Immunomodulation by adipokines in type 1 diabetes
- Adiponectin and interleukin-6 in inflammation-associated disease.
- Calcium and Leucine Modulation of Airway Inflammation
- Adiponectin and cardiovascular disease: response to therapeutic interventions.
- Novel mechanisms involved with lipid metabolism in adipose tissue of dairy cows
- Dynamic interplay between metabolic syndrome and immunity.
- Метаболический синдром при ревматоидном артрите
- Associations Between Weight Loss and Regain, Cytokine Concentration, and Insulin Resistance Among Overweight/Obese Adults
- The Evolving Role of Leptin and Adiponectin in Chronic Liver Diseases
- Serum adiponectin levels in children with nonspecific infections
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