Idiotype-anti-idiotype network. II. Activation of silent clones by treatment at birth with idiotypes is associated with the expansion of idiotype-specific helper T cells
Explore this paper's citation graph
Summary
It is proposed that this idiotype-induced idiotype response, which can be, in principal, induced by idiotypes provided by the mother, plays an important role in the expansion of precursors of antibody-forming cells during embryonic as well as postnatal life.
- Type
- article
- Published
- 1982-08-01
- Cited by
- 100
- References
- 26
- Access
- Open access
- OpenAlex
- https://openalex.org/W1984292723
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:83639393
Keywords
Idiotype, Idiotopes, Epitope, Monoclonal antibody, Immunoglobulin Idiotypes
References
- Activation of the guinea pig alternative complement pathway by mouse IgA immune complexes
- Thymus-independent antigens: the preparation of covalent, hapten-ficoll conjugates.
- Immune response to levan. I. Kinetics and ontogeny of anti-levan and anti-inulin antibody response and of expression of cross-reactive idiotype.
- Influenza as a problem in immunology.
- THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.
- Idiotypes and lymphocytes
- Tritium (3H) radiolabeling of protein A and antibody to high specific activity: application to cell surface antigen radioimmunoassays.
- T-cell proliferative response to hapten-modified self-immunoglobulins: recognition of conjugate-specific determinants.
- Direct and indirect suppression induced by anti-idiotype antibody in the inulin-bacterial levan antigenic system.
- Regulatory idiotopes and immune networks: a hypothesis.
- T lymphocyte-mediated suppression of myeloma function in vitro. II. Evidence for regulation of hapten-binding myelomas by syngeneic hapten- specific cytolytic T lymphocytes
- Shared idiotypes among monoclonal antibodies specific for different immunodominant sugars of lipopolysaccharide of different Gram-negative bacteria.
- Synthesis and use of O-stearoyl polysaccharides in passive hemagglutination and hemolysis.
- Multiple individual and cross-specific indiotypes on 13 levan-binding myeloma proteins of BALB/c mice
- Immunoregulatory role of maternal idiotypes. Ontogeny of immune networks
- Neonatal treatment with low doses of anti-idiotypic antibody leads to the expression of a silent clone
- Idiotype-anti-idiotype regulation. I. Immunization with a levan-binding myeloma protein leads to the appearance of auto-anti-(anti-idiotype) antibodies and to the activation of silent clones
- Cellular basis of regulation of expression of idiotype. II. Immunity to anti-MOPC-460 idiotype antibodies increases the level of anti- trinitrophenyl antibodies bearing 460 idiotypes
- Genetic and cellular regulation of the expression of specific antibody idiotypes in the anti-polyfructosan immune response.
- Assessing B cell diversification by antigen receptor and precursor cell analysis.
Cited by
- Role of variable region gene expression and environmental selection in determining the antiphosphorylcholine B cell repertoire
- Internal Image Concept Revisited 1
- Molecular identification of pathogenetic IdLNF+1 autoantibody idiotypes derived from the NZBxSWR F1 model for systemic lupus erythematosus.
- Network regulation of the immune response to bacterial polysaccharide antigens.
- The clonotype repertoire of B cell subpopulations.
- Regulation of rabbit allotypes
- Generalization of single immunological experiences by idiotypically mediated clonal connections.
- Regulation of myeloma growth in mice by antigen and regulatory idiotopes.
- A predominant idiotype independent of specificity, or Ig and H‐2 allotypes, is found in the primary but not the secondary murine antibody response to lysozyme
- Helper T cells reacting to idiotype on IgG but not IgM
- Antibodies Given Orally in the Neonatal Period Can Affect the Immune Response for Two Generations: Evidence for Active Maternal Influence on the Newborn's Immune System
- Structural Correlates of a Regulatory Idiotope
- Repertoire expression in surface immunoglobulin-negative bone marrow B cell precursors.
- Molecular characterization of the VH region of murine autoantibodies from neonatal and adult BALB/c mice
- Identification and characterization of a hapten-modifiable TEPC 15 cross-reactive idiotype in swine.
- Exposure of female mice to type II collagen reduces susceptibility to collagen‐induced arthritis in offspring
- Idiotypic Regulation of Development of the B‐Cell Repertoire
- The role of the A48 regulatory idiotype in inducing tumor-specific immunity.
- Xenogeneic antibodies and atopic disease.
- Lamarckian inheritance by somatically acquired maternal IgG phenotypes.
Related papers
- An idiotypic determinant formed by both immunoglobulin constant and variable regions
- Syngeneic anti-idiotypes against monoclonal anti-HLA-DR antibodies: characterization of recurrent idiotopes.
- Molecular basis for expression of the A48 regulatory idiotope on antibodies encoded by immunoglobulin variable-region genes from various families.
- The expression of a private idiotope requires pretreatment with noncomplementary anti-idiotypic antibodies.
- Sequential anti-idiotypes define reciprocal idiotopes on the same anti-DNA antibody.
- Idiotype-anti-idiotype interactions and the control of the anti-beta (2 leads to 6) polyfructosan response in the mouse: specificity and idiotypy of anti-ABPC48 anti-idiotypic monoclonal antibodies.
- Gene repertoire of the anti-poly(Glu60Ala30Tyr10) (GAT) immune response: comparison of VH, V kappa, and D regions used by anti-GAT antibodies and monoclonal antibodies produced after anti-idiotypic immunization.
- Expression and relationships of seven public idiotypes of DNA-binding autoantibodies on monoclonal antibodies and serum immunoglobulins.
- Idiotypic relationship of anti‐Ia.2 antibodies
- Public Idiotypes Shared by Monoclonal Antibodies Derived from Patients with Systemic Lupus Erythematosus or Leprosy