A cell cycle regulator potentially involved in genesis of many tumor types.
Explore this paper's citation graph
Summary
Findings suggest that MTS1 mutations are involved in tumor formation in a wide range of tissues.
- Type
- article
- Published
- 1994-04-15
- Cited by
- 3,014
- References
- 22
- OpenAlex
- https://openalex.org/W1983348452
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28305076
Keywords
Biology, Frameshift mutation, Tumor suppressor gene, Cancer research, Gene
References
- Frequent loss of chromosome 9p21-22 early in head and neck cancer progression.
- Homozygous loss of the interferon genes defines the critical region on 9p that is deleted in lung cancers.
- Homozygous deletions within 9p21-p22 identify a small critical region of chromosomal loss in human malignant mesotheliomas.
- Localization of chromosome 9p homozygous deletions in glioma cell lines with markers constituting a continuous linkage group.
- Characterization of a candidate bcl-1 gene
- Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit
- p53: at the crossroads of molecular carcinogenesis and risk assessment.
- A novel cyclin encoded by a bcl1-linked candidate oncogene
- PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma.
- Functional interactions of the retinoblastoma protein with mammalian D-type cyclins.
- WAF1, a potential mediator of p53 tumor suppression.
- All in the (cancer) family
- A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
- p21 is a universal inhibitor of cyclin kinases
- The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
- Homozygous deletion of the alpha- and beta 1-interferon genes in human leukemia and derived cell lines.
- Frequent loss of chromosome 9 in human primary non-small cell lung cancer.
- Homozygous deletions within human chromosome band 9p21 in melanoma.
- Deletions of interferon genes in acute lymphoblastic leukemia.
- Prevalence of RAS oncogene mutation in head and neck carcinomas.
Cited by
- CpG island methylation
- Genetic alterations in adult diffuse glioma: occurrence, significance, and prognostic implications.
- Gamma-interferon induces an irreversible growth arrest in mid-G1 in mammary epithelial cells which correlates with a block in hyperphosphorylation of retinoblastoma.
- Molecular changes in human melanoma metastasis.
- Loss of tumor suppressor gene expression in high-grade but not low-grade non-Hodgkin's lymphomas.
- Cellular effects of olomoucine, an inhibitor of cyclin‐dependent kinases
- 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
- Inhibitors of cyclin-dependent kinase and cancer
- Loss of heterozygosity analysis of keratoacanthoma reveals multiple differences from cutaneous squamous cell carcinoma.
- Inactivation of cyclin-dependent kinase inhibitor genes and development of human acute leukemias.
- Analysis of the Rb gene and cyclin-dependent kinase 4 inhibitor genes (p16INK4 and p15INK4B) in human ovarian carcinoma cell lines.
- Molecular aspects of neuro-oncology.
- Disruption of the RB pathway and cell‐proliferative activity in non‐small‐cell lung cancers
- Deletion of P15 (MTS2) in head and neck squamous cell carcinomas.
- Cell cycle profiles and expressions of p21CIP1 AND P27KIP1 during myocyte development.
- Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6.
- Molecular Genetic Parameters in Pathogenesis and Prognosis of Testicular Germ Cell Tumors
- Melanoma genetics: an update with focus on the CDKN2A(p16)/ARF tumor suppressors.
- Second-generation interferons for cancer: clinical targets.
- Overexpression of p16INK4A as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri
Related papers
- MMuFLR: missense mutation and frameshift location reporter
- A double mutation in a patient with X-linked myotubular myopathy.
- Missense mutation with/without nonsense mutation of the p53 gene is associated with large cell morphology in human malignant lymphoma
- Exon skipping induced by nonsense/frameshift mutations in DMD gene results in Becker muscular dystrophy
- Splice, Insertion‐Deletion and Nonsense Mutations that Perturb the Phenylalanine Hydroxylase Transcript Cause Phenylketonuria in India
- Systematic Mutation Screening of the Pro-Opiomelanocortin Gene: Identification of Several Genetic Variants Including Three Different Insertions, One Nonsense and Two Missense Point Mutations in Probands of Different Weight Extremes
- Early diagnosis of mucopolysaccharidosis III A with a nonsense mutation and two de novo missense mutations in SGSH gene
- Mutations are not uniformly distributed throughout the OCRL1 gene in Lowe syndrome patients.
- Frameshift and nonsense p53 mutations in squamous-cell carcinoma of head and neck - non-reactivity with 3 anti-p53 monoclonal-antibodies.