Functional interactions of the retinoblastoma protein with mammalian D-type cyclins.
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Summary
All D-type cyclins do not function equivalently, and one of them plays a major role in reversing the cycle-blocking function of a known tumor suppressor.
- Type
- article
- Published
- 1993-05-07
- Cited by
- 1,075
- References
- 60
- OpenAlex
- https://openalex.org/W2012293213
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:41911038
Keywords
Biology, Cyclin A, Retinoblastoma protein, Cyclin D1, E2F
References
- Tumor suppressor genes.
- The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.
- Proviral insertions near cyclin D1 in mouse lymphomas: a parallel for BCL1 translocations in human B-cell neoplasms.
- Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas.
- Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4.
- Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates.
- Independent regulation of human D-type cyclin gene expression during G1 phase in primary human T lymphocytes.
- Identification of HPV-16 E7 peptides that are potent antagonists of E7 binding to the retinoblastoma suppressor protein.
- Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides
- Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene.
- Characterization of a candidate bcl-1 gene
- A new technique for the assay of infectivity of human adenovirus 5 DNA.
- Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family.
- Cellular targets for transformation by the adenovirus E1A proteins.
- Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein.
- The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus.
- Regulation of retinoblastoma protein functions by ectopic expression of human cyclins.
- The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T.
- Genomic organization, chromosomal localization, and independent expression of human cyclin D genes.
- Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins.
Cited by
- Cyclin D1 (Bcl-1, PRAD1) protein expression in low-grade B-cell lymphomas and reactive hyperplasia.
- Disruption of retinoblastoma protein function by coexpression of its C pocket fragment.
- Molecular biological aspects of soft tissue tumors.
- Virus-encoded cyclin
- V3 Loop of Human Immunodeficiency Virus Type 1 Reduces Cyclin E Expression and Induces G1 Arrest in Interleukin 2-Dependent T Cells
- The role of cyclin E in cell proliferation, development and cancer.
- A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2
- Conditional transformation of rat embryo fibroblast cells by a cyclin D1-cdk4 fusion gene
- Lamin A/C, laminopathies and premature ageing.
- TGF-beta receptors and actions.
- The role of cyclin E in the regulation of entry into S phase.
- The consensus motif for phosphorylation by cyclin D1‐Cdk4 is different from that for phosphorylation by cyclin A/E‐Cdk2.
- Regulation of the cell cycle by the Rb tumor suppressor family.
- Histone modifications across the cell cycle in undifferentiated and differentiating mouse embryonic stem cells
- Integration of the PRB and P53 Cell Cycle Control Pathways
- Big brothers are watching: the retinoblastoma family and growth control.
- The co-modulation of apoptosis and the cell cycle
- In vivo studies of repressors of RNA polymerase III transcription
- Established and novel Cdk/cyclin complexes regulating the cell cycle and development.
- Expression and activity of the retinoblastoma protein (pRB)-family proteins, p107 and p130, during L6 myoblast differentiation.
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