Acute effects of short‐chain alkylglycerols on blood‐brain barrier properties of cultured brain endothelial cells
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Summary
Intra‐arterial injection of short‐chain alkylglycerols (AGs) opens the blood‐brain barrier and increases delivery of molecules to rodent brain parenchyma in vivo.
- Type
- article
- Published
- 2013-08-01
- Cited by
- 40
- References
- 56
- Access
- Open access
- OpenAlex
- https://openalex.org/W1505683203
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:32130733
Keywords
Tight junction, Paracellular transport, Blood–brain barrier, Immunostaining, Cell biology
References
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- Osmotic Opening of the Blood–Brain Barrier: Principles, Mechanism, and Therapeutic Applications
- Selective Paracellular Permeability in Two Models of Intestinal Absorption: Cultured Monolayers of Human Intestinal Epithelial Cells and Rat Intestinal Segments
- Puromycin‐based purification of rat brain capillary endothelial cell cultures. Effect on the expression of blood–brain barrier‐specific properties
- Modulation of tight junction structure in blood-brain barrier endothelial cells. Effects of tissue culture, second messengers and cocultured astrocytes.
- Elucidating the principles of the molecular organization of heteropolymeric tight junction strands
- Methotrexate loaded polyether-copolyester dendrimers for the treatment of gliomas: enhanced efficacy and intratumoral transport capability.
- FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE
- Drug and gene targeting to the brain with molecular trojan horses
- Modulation of the blood-brain barrier in oncology: therapeutic opportunities for the treatment of brain tumours?
- Penetration of small molecular weight substances through cultured bovine brain capillary endothelial cell monolayers: the early effects of cyclic adenosine 3',5'‐monophosphate
- Alkylglycerol opening of the blood–brain barrier to small and large fluorescence markers in normal and C6 glioma‐bearing rats and isolated rat brain capillaries
- RhoA, Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin.
- Hyperosmolar Opening of the Blood-Brain Barrier in the Energy-Depleted Rat Brain. Part 1. Permeability Studies
- Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood‐brain barrier for the treatment of patients with malignant brain tumors
- On the self-association potential of transmembrane tight junction proteins
- Paracellular diffusion in Caco-2 cell monolayers: effect of perturbation on the transport of hydrophilic compounds that vary in charge and size.
- Identification and Design of Peptides as a New Drug Delivery System for the Brain
- Increased delivery of erucylphosphocholine to C6 gliomas by chemical opening of the blood-brain barrier using intracarotid pentylglycerol in rats
Cited by
- A versatile lab-on-a-chip tool for modeling biological barriers
- Nanoparticles of alkylglyceryl-dextran-graft-poly(lactic acid) for drug delivery to the brain: Preparation and in vitro investigation.
- Tesmilifene modifies brain endothelial functions and opens the blood–brain/blood–glioma barrier
- Transfer of opiorphin through a blood-brain barrier culture model.
- Cyclodextrins, blood-brain barrier, and treatment of neurological diseases.
- Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study
- Delivery of Therapeutic Peptides and Proteins to the CNS
- Tight junction modulation of the blood brain barrier: CNS delivery of small molecules
- Blood-brain barrier co-culture models to study nanoparticle penetration: focus on co-culture systems
- Carbohydrate Nanoparticles for Brain Delivery.
- High-throughput screening for identification of blood-brain barrier integrity enhancers: a drug repurposing opportunity to rectify vascular amyloid toxicity
- Nanoparticles of alkylglyceryl dextran and poly(ethyl cyanoacrylate) for applications in drug delivery: Preparation and characterization
- Crossing the Blood–Brain Barrier: Recent Advances in Drug Delivery to the Brain
- Modulation of tight junctions by peptides to increase drug penetration across biological barriers
- Self‐assembled amphiphilic core‐shell nanocarriers in line with the modern strategies for brain delivery
- Freeze fracture: new avenues for the ultrastructural analysis of cells in vitro
- Reversible opening of the blood-brain barrier by claudin-5-binding variants of Clostridium perfringens enterotoxin's claudin-binding domain.
- Niosomes decorated with dual ligands targeting brain endothelial transporters increase cargo penetration across the blood‐brain barrier
- Tight junction proteins at the blood–brain barrier: far more than claudin-5
- A comprehensive review in improving delivery of small-molecule chemotherapeutic agents overcoming the blood-brain/brain tumor barriers for glioblastoma treatment
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