Effects of miltefosine on various biochemical parameters in a panel of tumor cell lines with different sensitivities.
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Summary
No correlation was found between resistance to miltefosine and endocytosis, intracellular concentration of milteFosine, the phospholipid and cholesterol content, induction of apoptosis, or cell cycle alterations in all the cell lines tested.
- Type
- article
- Published
- 2001-09-15
- Cited by
- 48
- References
- 42
- OpenAlex
- https://openalex.org/W1980376409
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23548556
Keywords
Miltefosine, HeLa, Apoptosis, Cell culture, Biology
References
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- A rapid single step staining technique for DNA analysis by flow microfluorimetry.
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Cited by
- Lipid rafts and metabolic energy differentially determine uptake of anti-cancer alkylphospholipids in lymphoma versus carcinoma cells.
- Miltefosine in the treatment of leishmaniasis: Clinical evidence for informed clinical risk management
- Mammalian phospholipid homeostasis: homeoviscous adaptation deconstructed by lipidomic data driven modelling.
- Lysosomal and mitochondrial pathways in miltefosine-induced apoptosis in U937 cells
- The AKT inhibitor perifosine in biochemically recurrent prostate cancer: a phase II California/Pittsburgh cancer consortium trial.
- Anticancer alkylphospholipids: mechanisms of action, cellular sensitivity and resistance, and clinical prospects.
- Recent progress in the discovery of Akt inhibitors as anticancer agents
- Phase II Study of Perifosine in Previously Untreated Patients with Metastatic Melanoma
- The anti-tumor alkylphospholipid perifosine is internalized by an ATP-dependent translocase activity across the plasma membrane of human KB carcinoma cells.
- Anticancer mechanisms and clinical application of alkylphospholipids.
- Structure-activity relationships of antineoplastic ring-substituted ether phospholipid derivatives
- Miltefosine for Old World cutaneous leishmaniasis: An experimental study on Leishmania major infected mice
- Possible Mechanism of Miltefosine-Mediated Death of Leishmania donovani
- Miltefosine Induces Apoptosis-Like Death in Leishmania donovani Promastigotes
- Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical use.
- Miltefosine, a promising novel agent for schistosomiasis mansoni.
- Proinflammatory and Cytotoxic Effects of Hexadecylphosphocholine (Miltefosine) against Drug-Resistant Strains of Trypanosoma cruzi
- A Phase II Trial of Perifosine in Locally Advanced, Unresectable, or Metastatic Pancreatic Adenocarcinoma
- Ultrastructural analysis of miltefosine-induced surface membrane damage in adult Schistosoma mansoni BH strain worms
- Miltefosine induces apoptosis in arsenite-resistant Leishmania donovani promastigotes through mitochondrial dysfunction.
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