Inositol trisphosphate and calcium signalling
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Summary
Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle.
- Type
- review
- Published
- 1993-01-28
- Cited by
- 6,430
- References
- 155
- OpenAlex
- https://openalex.org/W1980166477
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4362262
Keywords
Ryanodine receptor, Calcium, Inositol, Second messenger system, Calcium signaling
References
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- Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum.
- The size of inositol 1,4,5-trisphosphate-sensitive Ca2+ stores depends on inositol 1,4,5-trisphosphate concentration.
- Calmodulin is required for cell‐cycle progression during G1 and mitosis.
- The ligand binding site and transduction mechanism in the inositol‐1,4,5‐triphosphate receptor.
- Heterogeneity of microsomal Ca2+ stores in chicken Purkinje neurons.
- Purification and characterization of a new isozyme of thiol:protein-disulfide oxidoreductase from rat hepatic microsomes. Relationship of this isozyme to cytosolic phosphatidylinositol-specific phospholipase C form 1A.
- Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors.
- Regulation of inositol phospholipid-specific phospholipase C isozymes.
- Enhanced phospholipase C stimulation and transformation in NIH-3T3 cells expressing Q209LGq-alpha-subunits.
- Autophosphorylation of inositol 1,4,5-trisphosphate receptors.
- Enhancement of phospholipase C delta 1 activity in the aortas of spontaneously hypertensive rats.
- Mechanism of Ca2+ wave propagation in pancreatic acinar cells.
- Receptor-activated Ca2+ influx. Two independently regulated mechanisms of influx stimulation coexist in neurosecretory PC12 cells.
- Spontaneous cytosolic calcium oscillations driven by inositol trisphosphate occur during in vitro maturation of mouse oocytes.
- Activation of cytosolic phosphoinositide phospholipase C by G-protein beta gamma subunits.
- Pulsatile Ca2+ extrusion from single pancreatic acinar cells during receptor-activated cytosolic Ca2+ spiking.
- A differential location of phosphoinositide kinases, diacylglycerol kinase, and phospholipase C in the nuclear matrix.
- Oscillatory cytosolic calcium waves independent of stimulated inositol 1,4,5-trisphosphate formation in hepatocytes.
- The thiol reagent, thimerosal, evokes Ca2+ spikes in HeLa cells by sensitizing the inositol 1,4,5-trisphosphate receptor.
Cited by
- Extraction, separation, and analysis of plant phosphoinositides and complex glycolipids.
- The role of the intracellular signaling pathway in Ehrlichia canis infection in vitro
- Calcium transients in the garter snake vomeronasal organ.
- T cell signaling: a decision of life and death.
- Effect of dephostatin on intracellular free calcium concentration and amylase secretion in isolated rat pancreatic acinar cells
- Muscarinic modulation of the oscillatory and repetitive firing properties of entorhinal cortex layer II neurons.
- Inositol 1,4,5-trisphosphate-gated conductance in isolated rat olfactory neurons.
- Calcium oscillations and pacemaking.
- Activation mechanism of Ca(2+)‐sensitive transient outward current in rabbit ventricular myocytes.
- Substance P‐related antagonists inhibit vasopressin and bombesin but not 5′‐3‐O‐(thio) triphosphate‐stimulated inositol phosphate production in swiss 3T3 cells
- Intracellular calcium release induced by human immunodeficiency virus type 1 (HIV-1) surface envelope glycoprotein in human intestinal epithelial cells: a putative mechanism for HIV-1 enteropathy.
- Intercellular calcium waves mediated by diffusion of inositol trisphosphate: a two-dimensional model.
- [Ca2+]i oscillations in sympathetic neurons: an experimental test of a theoretical model.
- Chromatographic Resolution of an Intracellular Calcium Influx Factor from Thapsigargin-activated Jurkat Cells
- Intracellular calcium oscillations in a T-cell line after exposure to extremely-low-frequency magnetic fields with variable frequencies and flux densities.
- Suppression of ventricular arrhythmias during ischemia-reperfusion by agents inhibiting Ins(1,4,5)P3 release.
- Myocardial inositoltrisphosphate is depressed by dibutyryl cAMP. An experimental study in the isolated working rat heart.
- Low frequency MFs increased inositol 1,4,5‐trisphosphate levels in the Jurkat cell line
- Interleukin 4 receptor signaling in human monocytes and U937 cells involves the activation of a phosphatidylcholine-specific phospholipase C: a comparison with chemotactic peptide, FMLP, phospholipase D, and sphingomyelinase
- Intracellular Calcium: Questions about quantal Ca2+release
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