JOINT ANALYSIS OF SNP AND GENE EXPRESSION DATA IN GENETIC ASSOCIATION STUDIES OF COMPLEX DISEASES

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Summary

This paper proposes a variance component test for the total effect of SNPs and a gene expression on disease risk and applies the method to re-analyze the overall effect of the SNP-set and expression of the ORMDL3 gene on the risk of asthma.

Type
article
Published
2014-03-01
Cited by
102
References
51
Access
Open access

Keywords

Single-nucleotide polymorphism, Test statistic, Genetic association, Genome-wide association study, SNP

References

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