JOINT ANALYSIS OF SNP AND GENE EXPRESSION DATA IN GENETIC ASSOCIATION STUDIES OF COMPLEX DISEASES
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Summary
This paper proposes a variance component test for the total effect of SNPs and a gene expression on disease risk and applies the method to re-analyze the overall effect of the SNP-set and expression of the ORMDL3 gene on the risk of asthma.
- Type
- article
- Published
- 2014-03-01
- Cited by
- 102
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W1979676475
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20605246
Keywords
Single-nucleotide polymorphism, Test statistic, Genetic association, Genome-wide association study, SNP
References
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- From gene expression to disease risk
- A resampling method based on pivotal estimating functions
- Variance component testing in generalised linear models with random effects
- Identification, Inference and Sensitivity Analysis for Causal Mediation Effects
- Integrating Pathway Analysis and Genetics of Gene Expression for Genome-wide Association Study of Basal Cell Carcinoma
- Rare Variants Create Synthetic Genome-Wide Associations
- Mapping determinants of human gene expression by regional and genome-wide association
- Bayesian Inference for Causal Effects: The Role of Randomization
- Genetic analysis of genome-wide variation in human gene expression
- Epigenome dynamics: a quantitative genetics perspective
- A Score Based Approach to Wild Bootstrap Inference
Cited by
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- Hypothesis test of mediation effect in causal mediation model with high‐dimensional continuous mediators
- iGWAS: Integrative Genome-Wide Association Studies of Genetic and Genomic Data for Disease Susceptibility Using Mediation Analysis
- A Retrospective Likelihood Approach for Efficient Integration of Multiple Omics Factors in Case‐Control Association Studies
- Rare-variant association analysis: study designs and statistical tests.
- Integrative modeling of multiple genomic data from different types of genetic association studies.
- Integrative analysis of multiple diverse omics datasets by sparse group multitask regression
- Integrative modeling of multi-platform genomic data under the framework of mediation analysis
- Aberrant Expression of Shared Master-Key Genes Contributes to the Immunopathogenesis in Patients with Juvenile Spondyloarthritis
- Statistical Methods in Integrative Genomics
- Measuring epigenetics as the mediator of gene/environment interactions in DOHaD
- Prospects for clinical use of reprogrammed cells for autologous treatment of macular degeneration
- Mediation analysis in genome-wide association studies: current perspectives
- Integrative Analysis of Multi-omics Data for Discovery and Functional Studies of Complex Human Diseases
- Strategies for Integrated Analysis of Genetic, Epigenetic, and Gene Expression Variation in Cancer: Addressing the Challenges
- Integrative genomic testing of cancer survival using semiparametric linear transformation models
- MOPED 2.5—An Integrated Multi-Omics Resource: Multi-Omics Profiling Expression Database Now Includes Transcriptomics Data
- Clustering high‐dimensional mixed data to uncover sub‐phenotypes: joint analysis of phenotypic and genotypic data
- Exploiting expression patterns across multiple tissues to map expression quantitative trait loci
- Implementation and reporting of causal mediation analysis in 2015: a systematic review in epidemiological studies
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