VEGFR1 Activity Modulates Myeloid Cell Infiltration in Growing Lung Metastases but Is Not Required for Spontaneous Metastasis Formation
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Summary
It is demonstrated that blockade of VEGFR1 activity neither prevents nor changes the rate of spontaneous metastasis formation after primary tumor removal, and prevention of metastasis will require further identification and exploration of cellular and molecular pathways that mediate the priming of the metastatic soil.
- Type
- article
- Published
- 2009-09-18
- Cited by
- 49
- References
- 27
- Access
- Open access
- OpenAlex
- https://openalex.org/W1979649494
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:228691
Keywords
Metastasis, Cancer research, Primary tumor, Myeloid, Blockade
References
- Tumour-educated macrophages promote tumour progression and metastasis
- Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
- Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor
- Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis
- Paradoxical roles of the immune system during cancer development
- Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis
- Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors.
- Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors.
- Lessons from phase III clinical trials on anti-VEGF therapy for cancer
- FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?
- MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis.
- Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes
- Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?
- Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
- Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice.
- VEGFR1-activity-independent metastasis formation
- Anti-Vascular Endothelial Growth Factor Receptor-1 Antagonist Antibody as a Therapeutic Agent for Cancer
- Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels.
- TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4.
- Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: results of NSABP protocol C-08.
Cited by
- Direct evidence for lineage-dependent effects of bone marrow stromal cells on tumor progression
- Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models
- A novel intracellular isoform of VEGFR‐1 activates Src and promotes cell invasion in MDA‐MB‐231 breast cancer cells
- Vascular endothelial growth factor plays a critical role in the formation of the pre-metastatic niche via prostaglandin E2.
- The controversial role of placental growth factor in tumor growth.
- Ecosystems of invasion and metastasis in mammary morphogenesis and cancer.
- Myeloid cells
- PlGF blockade does not inhibit angiogenesis during primary tumor growth.
- C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells
- TIMP-2 targets tumor associated-myeloid suppressor cells with effects in cancer immune dysfunction and angiogenesis
- The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis
- Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease.
- Macrophage Diversity Enhances Tumor Progression and Metastasis
- Placental growth factor in cancer
- Vascular endothelial growth factors and receptors: anti-angiogenic therapy in the treatment of cancer.
- Complexity of tumor vasculature and molecular targeting therapies.
- VEGFR1-activity-independent metastasis formation
- PlGF: a multitasking cytokine with disease-restricted activity.
- The pro‐metastatic role of bone marrow‐derived cells: a focus on MSCs and regulatory T cells
- microRNA-155 deficiency in bone marrow results in enhanced tumor metastasis
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