Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury.
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Summary
Co-administration of l-buthionine sulfoximine (10mM in drinking water), an inhibitor of glutathione (GSH) synthesis, unexpectedly prevented the Tro-dependent increase of ALT, which suggests that the GSH scavenging pathway will not be involved in Tro-induced liver injury.
- Type
- article
- Published
- 2012-10-02
- Cited by
- 40
- References
- 34
- OpenAlex
- https://openalex.org/W1979018219
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6054943
Keywords
Liver injury, Troglitazone, Pharmacology, Glutathione, Buthionine sulfoximine
References
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- Diabetic KKAy mice exhibit increased hepatic PPARgamma1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones.
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- Estradiol and progesterone modulate halothane-induced liver injury in mice.
- In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver.
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- Effect of troglitazone on the liver of a Gunn rat model of genetic enzyme polymorphism.
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- Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo.
- Characterization of UDP-glucuronosyltransferases (UGTS) involved in the metabolism of troglitazone in rats and humans.
- Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers
- EXPRESSION OF HUMAN CYTOCHROMES P450 IN CHIMERIC MICE WITH HUMANIZED LIVER
- Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.
Cited by
- Mouse Models as Predictors of Human Responses: Evolutionary Medicine
- A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity.
- Preventing Drug-Induced Liver Injury: How Useful Are Animal Models?
- Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics.
- Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound
- Troglitazone metabolism and transporter effects in chimeric mice: a comparison between chimeric humanized and chimeric murinized FRG mice
- Endoplasmic Reticulum Stress in Drug- and Environmental Toxicant-Induced Liver Toxicity
- Chimeric rodents with humanized liver: bridging the preclinical/clinical trial gap in ADME/toxicity studies
- PRIMA-1Met induces myeloma cell death independent of p53 by impairing the GSH/ROS balance.
- Endogenous and xenobiotic metabolite profiling of liver extracts from SCID and chimeric humanized mice following repeated oral administration of troglitazone
- Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver
- Transgenic mice and metabolomics for study of hepatic xenobiotic metabolism and toxicity
- Mice with human livers.
- Chimeric Mice with Hepatocyte-humanized Liver as an Appropriate Model to Study Human Peroxisome Proliferator–activated Receptor-α
- Requirements for human iPS cell-derived hepatocytes as an alternative to primary human hepatocytes for assessing absorption, distribution, metabolism, excretion and toxicity of pharmaceuticals
- Advances in Engineered Liver Models for Investigating Drug-Induced Liver Injury
- Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver.
- P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity
- Chimeric Mice With Humanized Livers Demonstrate Human-Specific Hepatotoxicity Caused by a Therapeutic Antibody Against TRAIL-Receptor 2/Death Receptor 5
- Establishment of a mouse model of troglitazone‐induced liver injury and analysis of its hepatotoxic mechanism
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