Autophagic substrate clearance requires activity of the syntaxin-5 SNARE complex
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Summary
These findings provide a novel link between a fundamental process such as intracellular trafficking and human diseases that might be affected by defective biogenesis and/or homeostasis of the autophagosome–lysosome degradation system.
- Type
- article
- Published
- 2011-02-01
- Cited by
- 113
- References
- 64
- Access
- Open access
- OpenAlex
- https://openalex.org/W1978991502
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7007101
Keywords
Autophagy, Cell biology, Biology, Lysosome, Syntaxin
References
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- TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways.
- LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
- Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor.
- Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae
- Quality control in the endoplasmic reticulum.
- Endoplasmic Reticulum Stress Triggers Autophagy*
- SNAREs and traffic.
- Potential therapeutic applications of autophagy
- Autophagy fights disease through cellular self-digestion
- Fc gamma receptor-mediated phagocytosis requires tyrosine kinase activity and is ligand independent.
- Methodological considerations for assessing autophagy modulators: A study with calcium phosphate precipitates
- SNAREs — engines for membrane fusion
Cited by
- Molecular machinery of macroautophagy and its deregulation in diseases.
- Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells
- Rôle des protéines SNARE au niveau de la vacuole bactérienne durant les phases précoces de l'infection par Yersinia pseudotuberculosis dans un contexte d'autophagie
- ER and Golgi stresses increase ER-Golgi SNARE Syntaxin5: Implications for organelle stress and βAPP processing.
- Aberrant microRNA expression in spinal muscular atrophy motor neurons
- Age-dependent changes in rat lacrimal gland anti-oxidant and vesicular related protein expression profiles
- Measurement of Autophagic Activity in Mammalian Cells
- Autophagic digestion of Leishmania major by host macrophages is associated with differential expression of BNIP3, CTSE, and the miRNAs miR-101c, miR-129, and miR-210
- Autophagy in the physiology and pathology of the central nervous system
- Defective autophagy in spastizin mutated patients with hereditary spastic paraparesis type 15.
- A comprehensive glossary of autophagy-related molecules and processes (2nd edition)
- Modulating macroautophagy: a neuronal perspective
- Conditional repression of essential chloroplast genes: Evidence for new plastid signaling pathways.
- Autophagy modulation as a potential therapeutic target for diverse diseases
- Diverse Autophagosome Membrane Sources Coalesce in Recycling Endosomes
- Molecules and their functions in autophagy
- Involvement of members of the Rab family and related small GTPases in autophagosome formation and maturation
- Radiation persistently promoted oxidative stress, activated mTOR via PI3K/Akt, and downregulated autophagy pathway in mouse intestine
- Transcriptional Repressor DAXX Promotes Prostate Cancer Tumorigenicity via Suppression of Autophagy*
- Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis
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