Peripheral Blood “Endothelial Progenitor Cells” Are Derived From Monocyte/Macrophages and Secrete Angiogenic Growth Factors
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Summary
The findings suggest that acetylated LDL(+)ulex-lectin(+) cells, commonly referred to as EPCs, do not proliferate but release potent proangiogenic growth factors, which may allow for development of novel angiogenic therapies relying on secreted growth factors or on recruitment of endogenous monocytes/macrophages to sites of ischemia.
- Type
- article
- Published
- 2003-03-04
- Cited by
- 1,823
- References
- 24
- Access
- Open access
- OpenAlex
- https://openalex.org/W1978859651
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23894937
Keywords
Progenitor cell, Angiogenesis, Immunology, Vascular endothelial growth factor, Growth factor
References
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- Comparative study assessing effects of sonic hedgehog and VEGF in a human co-culture model for bone vascularisation strategies.
- Ilościowa ocena krążących komórek śródbłonka, krążących komórek progenitorowych i czynnika von Willebranda u kobiet w ciąży powikłanej nadciśnieniem tętniczym
- Cellular Therapy for Cardiovascular Disease Part 1 - Preclinical Insights
- Physiologie du compartiment endothélial circulant dans l’hypertension artérielle pulmonaire et perspectives de développement d’un produit de thérapie cellulaire
- Cell-derived Microparticles as Part of Multimarker Strategies to Improve Vascular Risk Prediction
- Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration
- Endothelial progenitor cells: isolation and characterization.
- Differentiation of endothelial cells from human umbilical cord blood AC133−CD14+ cells
- Beneficial effects of concurrent autologous bone marrow cell therapy and metabolic intervention in ischemia-induced angiogenesis in the mouse hindlimb.
- Heart repair and stem cells
- High Glucose Impairs Early and Late Endothelial Progenitor Cells by Modifying Nitric Oxide–Related but Not Oxidative Stress–Mediated Mechanisms
- Are postnatal hemangioblasts generated by dedifferentiation from committed hematopoietic stem cells?
- Stromal regulation of cancer growth: a balancing act in surgery.
- ECM-Based Materials in Cardiovascular Applications: Inherent Healing Potential and Augmentation of Native Regenerative Processes
- Platelet Microparticles Enhance the Vasoregenerative Potential of Angiogenic Early Outgrowth Cells After Vascular Injury
- Hypoxia regulates the production and activity of glucose transporter‐1 and indoleamine 2,3‐dioxygenase in monocyte‐derived endothelial‐like cells: possible relevance to infantile haemangioma pathogenesis
- Leukemia stem cells and microenvironment: biology and therapeutic targeting.
- Wnt1 is a proangiogenic molecule, enhances human endothelial progenitor function, and increases blood flow to ischemic limbs in a HGF‐dependent manner
- Endothelial Progenitor Cells Promote Astrogliosis following Spinal Cord Injury through Jagged1-Dependent Notch Signaling
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