Amino acid substitution during functionally constrained divergent evolution of protein sequences.
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Summary
The matrices show that the genetic code influences accepted point mutations strongly at early stages of divergence, while the chemical properties of the side chains dominate at more advanced stages.
- Type
- article
- Published
- 1994-11-01
- Cited by
- 169
- References
- 2
- Access
- Open access
- OpenAlex
- https://openalex.org/W1978667203
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:38284555
Keywords
Point mutation, Amino acid, Sequence (biology), Genetic code, Mutation
References
No references recorded for this paper.
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- Divide-and-Conquer Multiple Sequence Alignment
- Scoring residue conservation
- Unearthing the Root of Amino Acid Similarity
- An Alternative Look at Code Evolution: Using Non-canonical Codes to Evaluate Adaptive and Historic Models for the Origin of the Genetic Code
- Two Families of Mechanosensitive Channel Proteins
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