Stage-specific immune responses in human Necator americanus infection
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Summary
It is proposed that the longevity of hookworms in their human hosts results from a stage‐specific, down‐modulation of the immune response, resulting in diminished TNF‐α and IL‐10 secretion in peripheral blood mononuclear cells from hookworm infected patients.
- Type
- article
- Published
- 2007-07-01
- Cited by
- 67
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W1977931863
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1191545
Keywords
Necator americanus, Immune system, Biology, Immunology, Antigen
References
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- Removal of Regulatory T Cell Activity Reverses Hyporesponsiveness and Leads to Filarial Parasite Clearance In Vivo1
- A Secreted Protein from the Human Hookworm Necator americanus Binds Selectively to NK Cells and Induces IFN-γ Production
- Immunity after treatment of human schistosomiasis: association between cellular responses and resistance to reinfection
- The role of CD4+ and CD8+ T cells in protective immunity to the murine nematode parasite Trichuris muris
- Heligmosomoides polygyrus: CD4+ but not CD8+ T cells regulate the IgE response and protective immunity in mice.
- Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogs.
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- CD8+CD28− T suppressor cells and the induction of antigen‐specific, antigen‐presenting cell‐mediated suppression of Th reactivity
- Successful vaccination of BALB/c mice against human hookworm (Necator americanus): the immunological phenotype of the protective response.
- Evidence that cellular immune responses to soluble and membrane associated antigens are independently regulated during human schistosomiasis mansoni
- Necator americanus and Ancylostoma duodenale: life history parameters and epidemiological implications of two sympatric hookworms of humans.
- Stage-specific induction of cytokines regulates the immune response in lymphatic filariasis.
- Statistical analysis of highly skewed immune response data.
- Cellular responses and cytokine profiles in Ascaris lumbricoides and Trichuris trichiura infected patients
Cited by
- Binding of Excreted and/or Secreted Products of Adult Hookworms to Human NK Cells in Necator americanus-Infected Individuals from Brazil
- Helminth Therapy for MS.
- Atopic disorders and parasitic infections.
- Human cytokine responses during natural and experimental exposure to parasitic helminth infection
- Exposure to hookworms in patients with Crohn’s disease: a case‐control study
- Helmintos parásitos de importancia veterinaria: regulación de la respuesta inmunitaria del portador y su uso potencial para el tratamiento de enfermedades inflamatorias
- Prednisolone and cyclosporine A: effects on an experimental model of ancylostomiasis.
- Excretory-Secretory Products from Hookworm L3 and Adult Worms Suppress Proinflammatory Cytokines in Infected Individuals
- Molecular cloning and characterisation of in vitro immune response against astacin-like metalloprotease Ace-MTP-2 from Ancylostoma ceylanicum.
- Albendazole treatment of HIV-1 and helminth co-infection: A randomized, double blind, placebo-controlled trial
- Hookworm virulence factors: making the most of the host.
- Necator americanus and Helminth Co-Infections: Further Down-Modulation of Hookworm-Specific Type 1 Immune Responses
- Necator americanus Infection: A Possible Cause of Altered Dendritic Cell Differentiation and Eosinophil Profile in Chronically Infected Individuals
- Evidence of Microbial Translocation Associated with Perturbations in T Cell and Antigen-Presenting Cell Homeostasis in Hookworm Infections
- Do helminth parasites protect against atopy and allergic disease?
- Mucosal immunology of geohelminth infections in humans
- Species-specific treatment effects of helminth/HIV-1 co-infection: a systematic review and meta-analysis
- Induction of CD4+CD25+FOXP3+ Regulatory T Cells during Human Hookworm Infection Modulates Antigen-Mediated Lymphocyte Proliferation
- A one shot blood phenotype can identify sheep that resist Haemonchus contortus challenge.
- A history of hookworm vaccine development
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