Characterization of the two nonallelic genes encoding mouse preproinsulin
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Summary
The mouse preproinsulin I gene is missing the second intervening sequence that normally interrupts the C-peptide region in other insulin genes, and its homology to the preProinsulin II genes extends for only about 500 base pairs.
- Type
- article
- Published
- 2005-01-01
- Cited by
- 107
- References
- 50
- OpenAlex
- https://openalex.org/W1977706274
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10309671
Keywords
Biology, Gene, Homology (biology), Genetics, Nucleic acid sequence
References
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- RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon
- Carp preproinsulin cDNA sequence and evolution of insulin genes
- Role of the conserved AAUAAA sequence: four AAUAAA point mutants prevent messenger RNA 3' end formation.
- Comparison of the nucleic acid sequence of anglerfish and mammalian insulin mRNA's from cloned cDNA's.
- The evolution of genes: the chicken preproinsulin gene.
- Construction of coliphage lambda Charon vectors with BamHI cloning sites.
- A convenient and adaptable package of computer programs for DNA and protein sequence management, analysis and homology determination
- Three regions upstream from the cap site are required for efficient and accurate transcription of the rabbit β-globin gene in mouse 3T6 cells
- Screening lambdagt recombinant clones by hybridization to single plaques in situ.
- Sequence of the human insulin gene
- Extraction of nucleic acids from agarose gels.
- Action of single-strand specific nucleases on model DNA heteroduplexes of defined size and sequence.
- A bacterial clone synthesizing proinsulin.
- The structure and evolution of the two nonallelic rat preproinsulin genes.
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- Promoter elements in endocrine pancreas development and hormone regulation
- Differentiation of pancreatic and hepatic cell types
- Nephrin and the Pathogenesis of Nephropathy - Emphasis on Type I Diabetes
- Tolerance to Proinsulin-2 Is Due to Radioresistant Thymic Cells1
- Body window-enabled in vivo multicolor imaging of transplanted mouse islets expressing an insulin-Timer fusion protein.
- Empreinte génomique parentale et petits ARN non-codants
- Expression of Preproinsulin-2 Gene Shapes the Immune Response to Preproinsulin in Normal Mice1
- Insulin expressing hepatocytes not destroyed in transgenic NOD mice
- Modeling chick to assess diabetes pathogenesis and treatment.
- SENSORY NEURON INSULIN SIGNALING AND ITS ROLE IN DIABETIC NEUROPATHY
- Insulin Gene Expression Is Regulated by DNA Methylation
- Central and peripheral autoantigen presentation in immune tolerance
- Identification of 11 pseudogenes in the DNA methyltransferase gene family in rodents and humans and implications for the functional loci.
- Neuroendocrinology of protochordates: insights from Ciona genomics.
- Insulin is imprinted in the placenta of the marsupial, Macropus eugenii.
- Origins of new male germ-line functions from X-derived autosomal retrogenes in the mouse.
- Deregulation of CREB Signaling Pathway Induced by Chronic Hyperglycemia Downregulates NeuroD Transcription
- In Vivo Detection of Extrapancreatic Insulin Gene Expression in Diabetic Mice by Bioluminescence Imaging
- Clarification of the INS2 gene sequence: Relevance to glucose intolerance in NON/Lt mice
- Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter‐firefly luciferase transgene
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