Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes.
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Summary
This work has identified Pyrococcus furiosus Cas6 as a novel endoribonuclease that cleaves CRISPR RNAs within the repeat sequences to release individual invader targeting RNAs.
- Type
- article
- Published
- 2008-12-15
- Cited by
- 570
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W1977531433
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20660178
Keywords
Biology, Endoribonuclease, Computational biology, Evolutionary biology, RNA
References
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Cited by
- H‐NS‐mediated repression of CRISPR‐based immunity in Escherichia coli K12 can be relieved by the transcription activator LeuO
- Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA
- Adaptation and modification of three CRISPR loci in two closely related cyanobacteria
- CRISPR-Cas Immunity against Phages: Its Effects on the Evolution and Survival of Bacterial Pathogens
- Genome-directed analysis of prophage excision, host defence systems, and central fermentative metabolism in Clostridium pasteurianum
- Required base complementarity between guide RNAs and target sequences in the CRISPR-Cas-based virus defense mechanism of the hyperthermophilic archaeon Sulfolobus solfataricus
- Biochemical analysis of the Cas6-1 RNA endonuclease associated with the subtype I-D CRISPR-Cas system in Synechocystis sp. PCC 6803
- Bioinformatic analysis of RNA from diverse species
- Role of CRISPR/cas system in the development of bacteriophage resistance.
- The origin of the bacterial immune response.
- The CRISPR endoribonuclease Csy4 utilizes unusual sequence- and structure-specific mechanisms to recognize and process crRNAs
- Barriers to Horizontal Gene Transfer in Campylobacter jejuni.
- CRISPR-Cas Systems: RNA-mediated Adaptive Immunity in Bacteria and Archaea
- Regulatory RNAs in Prokaryotes
- Systems Metabolic Engineering of Escherichia coli
- Co-transcriptional DNA and RNA cleavage during type III CRISPR-Cas immunity
- Crystal structures of CRISPR-associated Csx3 reveal a manganese-dependent deadenylation exoribonuclease
- A conserved structural chassis for mounting versatile CRISPR RNA-guided immune responses
- Characterisation of proteins involved in CRISPR-mediated antiviral defence in Sulfolobus solfataricus
- CRISPR families of the crenarchaeal genus Sulfolobus: bidirectional transcription and dynamic properties
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